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Polymorphic sites preferentially avoid co-evolving residues in MHC class I proteins

Major histocompatibility complex class I (MHC-I) molecules are critical to adaptive immune defence mechanisms in vertebrate species and are encoded by highly polymorphic genes. Polymorphic sites are located close to the ligand-binding groove and entail MHC-I alleles with distinct binding specificiti...

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Detalles Bibliográficos
Autores principales:	Dib, Linda, Salamin, Nicolas, Gfeller, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983860/ https://www.ncbi.nlm.nih.gov/pubmed/29782520 http://dx.doi.org/10.1371/journal.pcbi.1006188

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