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Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF. Many viruses have evolved strategies to block TLR3-mediated interferon signaling via targeting TRIF. Here we studied how hepatitis C...

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Detalles Bibliográficos
Autores principales:	Liang, Yisha, Cao, Xuezhi, Ding, Qiang, Zhao, Yanan, He, Zhenliang, Zhong, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983870/ https://www.ncbi.nlm.nih.gov/pubmed/29782532 http://dx.doi.org/10.1371/journal.ppat.1007075

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