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Return to fertility after extended chemical castration with a GnRH antagonist

BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a Gn...

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Autores principales: Kostanski, Janusz W, Jiang, Ge, Dani, Bhas A, Murty, Santos B, Qiu, Wei, Schrier, Bruce, Thanoo, B C, DeLuca, Patrick P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59839/
https://www.ncbi.nlm.nih.gov/pubmed/11710965
http://dx.doi.org/10.1186/1471-2407-1-18
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author Kostanski, Janusz W
Jiang, Ge
Dani, Bhas A
Murty, Santos B
Qiu, Wei
Schrier, Bruce
Thanoo, B C
DeLuca, Patrick P
author_facet Kostanski, Janusz W
Jiang, Ge
Dani, Bhas A
Murty, Santos B
Qiu, Wei
Schrier, Bruce
Thanoo, B C
DeLuca, Patrick P
author_sort Kostanski, Janusz W
collection PubMed
description BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats. METHODS: Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After recovery of normal serum testosterone levels in the treated animals, each rat was housed with two proven breeder, but drug-naive, females. RESULTS: All mates of treated rats achieved pregnancy as rapidly as the mates of control rats although two of the control rats did not sire a litter with either female and one sired only one litter. The mean size of the litters of treated (12.3 offspring per litter) and control (10.6 offspring per litter) were similar. All offspring were grossly normal morphologically and behaviorally during the time to weaning. CONCLUSIONS: These results suggest that lack of fertility due to testosterone suppression is reversible after cessation of treatment with this GnRH antagonist.
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spelling pubmed-598392001-11-16 Return to fertility after extended chemical castration with a GnRH antagonist Kostanski, Janusz W Jiang, Ge Dani, Bhas A Murty, Santos B Qiu, Wei Schrier, Bruce Thanoo, B C DeLuca, Patrick P BMC Cancer Research Article BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats. METHODS: Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After recovery of normal serum testosterone levels in the treated animals, each rat was housed with two proven breeder, but drug-naive, females. RESULTS: All mates of treated rats achieved pregnancy as rapidly as the mates of control rats although two of the control rats did not sire a litter with either female and one sired only one litter. The mean size of the litters of treated (12.3 offspring per litter) and control (10.6 offspring per litter) were similar. All offspring were grossly normal morphologically and behaviorally during the time to weaning. CONCLUSIONS: These results suggest that lack of fertility due to testosterone suppression is reversible after cessation of treatment with this GnRH antagonist. BioMed Central 2001-10-29 /pmc/articles/PMC59839/ /pubmed/11710965 http://dx.doi.org/10.1186/1471-2407-1-18 Text en Copyright © 2001 Kostanski et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Kostanski, Janusz W
Jiang, Ge
Dani, Bhas A
Murty, Santos B
Qiu, Wei
Schrier, Bruce
Thanoo, B C
DeLuca, Patrick P
Return to fertility after extended chemical castration with a GnRH antagonist
title Return to fertility after extended chemical castration with a GnRH antagonist
title_full Return to fertility after extended chemical castration with a GnRH antagonist
title_fullStr Return to fertility after extended chemical castration with a GnRH antagonist
title_full_unstemmed Return to fertility after extended chemical castration with a GnRH antagonist
title_short Return to fertility after extended chemical castration with a GnRH antagonist
title_sort return to fertility after extended chemical castration with a gnrh antagonist
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59839/
https://www.ncbi.nlm.nih.gov/pubmed/11710965
http://dx.doi.org/10.1186/1471-2407-1-18
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