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Inhibition of DNA-PK activity sensitizes A549 cells to X-ray irradiation by inducing the ATM-dependent DNA damage response

Non-small cell lung cancer (NSCLC) is radioresistant to X-rays due to powerful cellular DNA damage repair mechanisms. DNA-dependent protein kinase (DNA-PK) is a key enzyme involved in DNA damage repair and the phenomenon and molecular mechanism of NSCLC radionsensitivity were investigated following...

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Detalles Bibliográficos
Autores principales:	Yang, Lina, Yang, Xinrui, Tang, Yiwei, Zhang, Defu, Zhu, Lijie, Wang, Shengnan, Wang, Bo, Ma, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983948/ https://www.ncbi.nlm.nih.gov/pubmed/29620203 http://dx.doi.org/10.3892/mmr.2018.8828

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