Cargando…

Inhibition of DNA-PK activity sensitizes A549 cells to X-ray irradiation by inducing the ATM-dependent DNA damage response

Non-small cell lung cancer (NSCLC) is radioresistant to X-rays due to powerful cellular DNA damage repair mechanisms. DNA-dependent protein kinase (DNA-PK) is a key enzyme involved in DNA damage repair and the phenomenon and molecular mechanism of NSCLC radionsensitivity were investigated following...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Lina, Yang, Xinrui, Tang, Yiwei, Zhang, Defu, Zhu, Lijie, Wang, Shengnan, Wang, Bo, Ma, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983948/ https://www.ncbi.nlm.nih.gov/pubmed/29620203 http://dx.doi.org/10.3892/mmr.2018.8828

Ejemplares similares

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

Impact of ATM and DNA-PK Inhibition on Gene Expression and Individual Response of Human Lymphocytes to Mixed Beams of Alpha Particles and X-Rays
por: Cheng, Lei, et al.
Publicado: (2019)

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
por: Burger, Kaspar, et al.
Publicado: (2019)

Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation
por: YANG, LINA, et al.
Publicado: (2015)

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA
por: Berthault, Nathalie, et al.
Publicado: (2022)

Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair
por: Anisenko, Andrey, et al.
Publicado: (2023)

High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate
por: Risso-Ballester, Jennifer, et al.
Publicado: (2019)

Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage
por: Trakarnphornsombat, Watanya, et al.
Publicado: (2023)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK
por: IMAMICHI, Shoji, et al.
Publicado: (2014)

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair
por: Serrano, Moises A., et al.
Publicado: (2012)

Stochastic multicellular modeling of x-ray irradiation, DNA damage induction, DNA free-end misrejoining and cell death
por: Forster, Jake C., et al.
Publicado: (2019)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest
por: Lundholm, L, et al.
Publicado: (2013)

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro
por: Tsuji, Toshiya, et al.
Publicado: (2017)

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair
por: Li, Zhiming, et al.
Publicado: (2018)

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
por: Guerra, Lina, et al.
Publicado: (2010)

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining
por: Lu, Huiming, et al.
Publicado: (2023)

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair
por: Tang, Ming, et al.
Publicado: (2019)

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
por: Aguilar-Quesada, Rocío, et al.
Publicado: (2007)

Field size effects on DNA damage and proliferation in normal human cell populations irradiated with X-ray microbeams
por: Ojima, Mitsuaki, et al.
Publicado: (2021)

Residual Foci of DNA Damage Response Proteins in Relation to Cellular Senescence and Autophagy in X-Ray Irradiated Fibroblasts
por: Osipov, Andrey, et al.
Publicado: (2023)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
por: Muñoz, Denise P., et al.
Publicado: (2013)

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
por: Calkins, Anne S., et al.
Publicado: (2013)

In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage
por: Sharma, Mukesh Kumar, et al.
Publicado: (2016)

DNA-PK(cs) promotes chromatin decondensation to facilitate initiation of the DNA damage response
por: Lu, Huiming, et al.
Publicado: (2019)

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
por: So, Sairei, et al.
Publicado: (2010)

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
por: So, Sairei, et al.
Publicado: (2009)

Recruitment and activation of the ATM kinase in the absence of DNA damage sensors
por: Hartlerode, Andrea J., et al.
Publicado: (2015)

Effect of X-ray irradiation on ancient DNA in sub-fossil bones – Guidelines for safe X-ray imaging
por: Immel, Alexander, et al.
Publicado: (2016)

PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair
por: Yu, Yue, et al.
Publicado: (2022)

Nucleus Near-Infrared (nNIR) Irradiation of Single A549 Cells Induces DNA Damage and Activates EGFR Leading to Mitochondrial Fission
por: Gbetuwa, Momoh, et al.
Publicado: (2022)

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
por: Tang, Jun, et al.
Publicado: (2013)

Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome
por: Ramadan, Emad, et al.
Publicado: (2008)

Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response
por: Quanz, Maria, et al.
Publicado: (2009)

Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response
por: Sun, Tingzhe, et al.
Publicado: (2017)

Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death
por: Tian, Bo, et al.
Publicado: (2009)

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response
por: Karlseder, Jan, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_vr0cgr5a0m295vd244rlh041de