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Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia-inducible factor-1α (HIF-1α) is activated by inhaled anesthetics. The aim of the present study was to...

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Detalles Bibliográficos
Autores principales:	Cao, Yiyun, Li, Zhengqian, Ma, Lijun, Ni, Cheng, Li, Lunxu, Yang, Ning, Shi, Chengmei, Guo, Xiangyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983961/ https://www.ncbi.nlm.nih.gov/pubmed/29620198 http://dx.doi.org/10.3892/mmr.2018.8850

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