Cargando…

The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer

Malignant pleural effusion (MPE) is a severe medical condition, which can result in breathlessness, pain, cachexia and reduced physical activity. It can occur in almost all types of malignant tumors; however, lung cancer is the most common cause of MPE, accounting for ~1/3 of clinical cases. Althoug...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yao, Mathy, Nicholas W., Lu, Hongda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983970/
https://www.ncbi.nlm.nih.gov/pubmed/29693703
http://dx.doi.org/10.3892/mmr.2018.8922
_version_ 1783328536077008896
author Chen, Yao
Mathy, Nicholas W.
Lu, Hongda
author_facet Chen, Yao
Mathy, Nicholas W.
Lu, Hongda
author_sort Chen, Yao
collection PubMed
description Malignant pleural effusion (MPE) is a severe medical condition, which can result in breathlessness, pain, cachexia and reduced physical activity. It can occur in almost all types of malignant tumors; however, lung cancer is the most common cause of MPE, accounting for ~1/3 of clinical cases. Although there are numerous therapeutic approaches currently available for the treatment of MPE, none are fully effective and the majority can only alleviate the symptoms of the patients. Vascular endothelial growth factor (VEGF) has now been recognized as one of the most important regulatory factors in tumor angiogenesis, which participates in the entire process of tumor growth through its function to stimulate tumor angiogenesis, activate host vascular endothelial cells and promote malignant proliferation. Novel drugs targeting VEGF, including endostar and bevacizumab, have been developed and approved for the treatment of various tumors. Data from recent clinical studies have demonstrated that drugs targeting VEGF are effective and safe for the clinical management of MPE. Therefore, VEGF-targeting represents a promising novel strategy for the diagnosis and treatment of MPE. The present review summarized recent advances in the role of VEGF in the pathogenesis, diagnosis and clinical management of MPE in patients with non-small cell lung cancer.
format Online
Article
Text
id pubmed-5983970
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-59839702018-06-04 The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer Chen, Yao Mathy, Nicholas W. Lu, Hongda Mol Med Rep Review Malignant pleural effusion (MPE) is a severe medical condition, which can result in breathlessness, pain, cachexia and reduced physical activity. It can occur in almost all types of malignant tumors; however, lung cancer is the most common cause of MPE, accounting for ~1/3 of clinical cases. Although there are numerous therapeutic approaches currently available for the treatment of MPE, none are fully effective and the majority can only alleviate the symptoms of the patients. Vascular endothelial growth factor (VEGF) has now been recognized as one of the most important regulatory factors in tumor angiogenesis, which participates in the entire process of tumor growth through its function to stimulate tumor angiogenesis, activate host vascular endothelial cells and promote malignant proliferation. Novel drugs targeting VEGF, including endostar and bevacizumab, have been developed and approved for the treatment of various tumors. Data from recent clinical studies have demonstrated that drugs targeting VEGF are effective and safe for the clinical management of MPE. Therefore, VEGF-targeting represents a promising novel strategy for the diagnosis and treatment of MPE. The present review summarized recent advances in the role of VEGF in the pathogenesis, diagnosis and clinical management of MPE in patients with non-small cell lung cancer. D.A. Spandidos 2018-06 2018-04-23 /pmc/articles/PMC5983970/ /pubmed/29693703 http://dx.doi.org/10.3892/mmr.2018.8922 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Chen, Yao
Mathy, Nicholas W.
Lu, Hongda
The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title_full The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title_fullStr The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title_full_unstemmed The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title_short The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
title_sort role of vegf in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983970/
https://www.ncbi.nlm.nih.gov/pubmed/29693703
http://dx.doi.org/10.3892/mmr.2018.8922
work_keys_str_mv AT chenyao theroleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer
AT mathynicholasw theroleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer
AT luhongda theroleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer
AT chenyao roleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer
AT mathynicholasw roleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer
AT luhongda roleofvegfinthediagnosisandtreatmentofmalignantpleuraleffusioninpatientswithnonsmallcelllungcancer