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Whole brain comparative anatomy using connectivity blueprints
Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984034/ https://www.ncbi.nlm.nih.gov/pubmed/29749930 http://dx.doi.org/10.7554/eLife.35237 |
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author | Mars, Rogier B Sotiropoulos, Stamatios N Passingham, Richard E Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A Sibson, Nicola Jbabdi, Saad |
author_facet | Mars, Rogier B Sotiropoulos, Stamatios N Passingham, Richard E Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A Sibson, Nicola Jbabdi, Saad |
author_sort | Mars, Rogier B |
collection | PubMed |
description | Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains. |
format | Online Article Text |
id | pubmed-5984034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59840342018-06-04 Whole brain comparative anatomy using connectivity blueprints Mars, Rogier B Sotiropoulos, Stamatios N Passingham, Richard E Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A Sibson, Nicola Jbabdi, Saad eLife Neuroscience Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains. eLife Sciences Publications, Ltd 2018-05-11 /pmc/articles/PMC5984034/ /pubmed/29749930 http://dx.doi.org/10.7554/eLife.35237 Text en © 2018, Mars et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Mars, Rogier B Sotiropoulos, Stamatios N Passingham, Richard E Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A Sibson, Nicola Jbabdi, Saad Whole brain comparative anatomy using connectivity blueprints |
title | Whole brain comparative anatomy using connectivity blueprints |
title_full | Whole brain comparative anatomy using connectivity blueprints |
title_fullStr | Whole brain comparative anatomy using connectivity blueprints |
title_full_unstemmed | Whole brain comparative anatomy using connectivity blueprints |
title_short | Whole brain comparative anatomy using connectivity blueprints |
title_sort | whole brain comparative anatomy using connectivity blueprints |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984034/ https://www.ncbi.nlm.nih.gov/pubmed/29749930 http://dx.doi.org/10.7554/eLife.35237 |
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