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Whole brain comparative anatomy using connectivity blueprints

Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of t...

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Autores principales: Mars, Rogier B, Sotiropoulos, Stamatios N, Passingham, Richard E, Sallet, Jerome, Verhagen, Lennart, Khrapitchev, Alexandre A, Sibson, Nicola, Jbabdi, Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984034/
https://www.ncbi.nlm.nih.gov/pubmed/29749930
http://dx.doi.org/10.7554/eLife.35237
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author Mars, Rogier B
Sotiropoulos, Stamatios N
Passingham, Richard E
Sallet, Jerome
Verhagen, Lennart
Khrapitchev, Alexandre A
Sibson, Nicola
Jbabdi, Saad
author_facet Mars, Rogier B
Sotiropoulos, Stamatios N
Passingham, Richard E
Sallet, Jerome
Verhagen, Lennart
Khrapitchev, Alexandre A
Sibson, Nicola
Jbabdi, Saad
author_sort Mars, Rogier B
collection PubMed
description Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains.
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spelling pubmed-59840342018-06-04 Whole brain comparative anatomy using connectivity blueprints Mars, Rogier B Sotiropoulos, Stamatios N Passingham, Richard E Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A Sibson, Nicola Jbabdi, Saad eLife Neuroscience Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains. eLife Sciences Publications, Ltd 2018-05-11 /pmc/articles/PMC5984034/ /pubmed/29749930 http://dx.doi.org/10.7554/eLife.35237 Text en © 2018, Mars et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mars, Rogier B
Sotiropoulos, Stamatios N
Passingham, Richard E
Sallet, Jerome
Verhagen, Lennart
Khrapitchev, Alexandre A
Sibson, Nicola
Jbabdi, Saad
Whole brain comparative anatomy using connectivity blueprints
title Whole brain comparative anatomy using connectivity blueprints
title_full Whole brain comparative anatomy using connectivity blueprints
title_fullStr Whole brain comparative anatomy using connectivity blueprints
title_full_unstemmed Whole brain comparative anatomy using connectivity blueprints
title_short Whole brain comparative anatomy using connectivity blueprints
title_sort whole brain comparative anatomy using connectivity blueprints
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984034/
https://www.ncbi.nlm.nih.gov/pubmed/29749930
http://dx.doi.org/10.7554/eLife.35237
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