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Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated...

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Autores principales: Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, O A, Arango, C, Banaj, N, Bouix, S, Bousman, C A, Brouwer, R M, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, J-x, Chen, X, Chiapponi, C, Cho, Kl K, Ciullo, V, Corvin, A S, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, C M, Dickie, E W, Ehrlich, S, Fan, F-m, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, J M, Fouche, J-P, Fukunaga, M, Gill, M, Glahn, D C, Gollub, R, Goudzwaard, E D, Guo, H, Gur, R E, Gur, R C, Gurholt, T P, Hashimoto, R, Hatton, S N, Henskens, F A, Hibar, D P, Hickie, I B, Hong, L E, Horacek, J, Howells, F M, Hulshoff Pol, H E, Hyde, C L, Isaev, D, Jablensky, A, Jansen, P R, Janssen, J, Jönsson, E G, Jung, L A, Kahn, R S, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, R K, Lim, K O, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, R C W, Mathalon, D H, McCarley, R W, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, R I, Michie, P T, Mowry, B, Mueller, B A, Newell, D T, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, S A, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, G R, Pereira, A, Pineda Zapata, J, Piras, F, Potkin, S G, Preda, A, Rasser, P E, Roalf, D R, Roiz, R, Roos, A, Rotenberg, D, Satterthwaite, T D, Savadjiev, P, Schall, U, Scott, R J, Seal, M L, Seidman, L J, Shannon Weickert, C, Whelan, C D, Shenton, M E, Kwon, J S, Spalletta, G, Spaniel, F, Sprooten, E, Stäblein, M, Stein, D J, Sundram, S, Tan, Y, Tan, S, Tang, S, Temmingh, H S, Westlye, L T, Tønnesen, S, Tordesillas-Gutierrez, D, Doan, N T, Vaidya, J, van Haren, N E M, Vargas, C D, Vecchio, D, Velakoulis, D, Voineskos, A, Voyvodic, J Q, Wang, Z, Wan, P, Wei, D, Weickert, T W, Whalley, H, White, T, Whitford, T J, Wojcik, J D, Xiang, H, Xie, Z, Yamamori, H, Yang, F, Yao, N, Zhang, G, Zhao, J, van Erp, T G M, Turner, J, Thompson, P M, Donohoe, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984078/
https://www.ncbi.nlm.nih.gov/pubmed/29038599
http://dx.doi.org/10.1038/mp.2017.170
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author Kelly, S
Jahanshad, N
Zalesky, A
Kochunov, P
Agartz, I
Alloza, C
Andreassen, O A
Arango, C
Banaj, N
Bouix, S
Bousman, C A
Brouwer, R M
Bruggemann, J
Bustillo, J
Cahn, W
Calhoun, V
Cannon, D
Carr, V
Catts, S
Chen, J
Chen, J-x
Chen, X
Chiapponi, C
Cho, Kl K
Ciullo, V
Corvin, A S
Crespo-Facorro, B
Cropley, V
De Rossi, P
Diaz-Caneja, C M
Dickie, E W
Ehrlich, S
Fan, F-m
Faskowitz, J
Fatouros-Bergman, H
Flyckt, L
Ford, J M
Fouche, J-P
Fukunaga, M
Gill, M
Glahn, D C
Gollub, R
Goudzwaard, E D
Guo, H
Gur, R E
Gur, R C
Gurholt, T P
Hashimoto, R
Hatton, S N
Henskens, F A
Hibar, D P
Hickie, I B
Hong, L E
Horacek, J
Howells, F M
Hulshoff Pol, H E
Hyde, C L
Isaev, D
Jablensky, A
Jansen, P R
Janssen, J
Jönsson, E G
Jung, L A
Kahn, R S
Kikinis, Z
Liu, K
Klauser, P
Knöchel, C
Kubicki, M
Lagopoulos, J
Langen, C
Lawrie, S
Lenroot, R K
Lim, K O
Lopez-Jaramillo, C
Lyall, A
Magnotta, V
Mandl, R C W
Mathalon, D H
McCarley, R W
McCarthy-Jones, S
McDonald, C
McEwen, S
McIntosh, A
Melicher, T
Mesholam-Gately, R I
Michie, P T
Mowry, B
Mueller, B A
Newell, D T
O'Donnell, P
Oertel-Knöchel, V
Oestreich, L
Paciga, S A
Pantelis, C
Pasternak, O
Pearlson, G
Pellicano, G R
Pereira, A
Pineda Zapata, J
Piras, F
Potkin, S G
Preda, A
Rasser, P E
Roalf, D R
Roiz, R
Roos, A
Rotenberg, D
Satterthwaite, T D
Savadjiev, P
Schall, U
Scott, R J
Seal, M L
Seidman, L J
Shannon Weickert, C
Whelan, C D
Shenton, M E
Kwon, J S
Spalletta, G
Spaniel, F
Sprooten, E
Stäblein, M
Stein, D J
Sundram, S
Tan, Y
Tan, S
Tang, S
Temmingh, H S
Westlye, L T
Tønnesen, S
Tordesillas-Gutierrez, D
Doan, N T
Vaidya, J
van Haren, N E M
Vargas, C D
Vecchio, D
Velakoulis, D
Voineskos, A
Voyvodic, J Q
Wang, Z
Wan, P
Wei, D
Weickert, T W
Whalley, H
White, T
Whitford, T J
Wojcik, J D
Xiang, H
Xie, Z
Yamamori, H
Yang, F
Yao, N
Zhang, G
Zhao, J
van Erp, T G M
Turner, J
Thompson, P M
Donohoe, G
author_facet Kelly, S
Jahanshad, N
Zalesky, A
Kochunov, P
Agartz, I
Alloza, C
Andreassen, O A
Arango, C
Banaj, N
Bouix, S
Bousman, C A
Brouwer, R M
Bruggemann, J
Bustillo, J
Cahn, W
Calhoun, V
Cannon, D
Carr, V
Catts, S
Chen, J
Chen, J-x
Chen, X
Chiapponi, C
Cho, Kl K
Ciullo, V
Corvin, A S
Crespo-Facorro, B
Cropley, V
De Rossi, P
Diaz-Caneja, C M
Dickie, E W
Ehrlich, S
Fan, F-m
Faskowitz, J
Fatouros-Bergman, H
Flyckt, L
Ford, J M
Fouche, J-P
Fukunaga, M
Gill, M
Glahn, D C
Gollub, R
Goudzwaard, E D
Guo, H
Gur, R E
Gur, R C
Gurholt, T P
Hashimoto, R
Hatton, S N
Henskens, F A
Hibar, D P
Hickie, I B
Hong, L E
Horacek, J
Howells, F M
Hulshoff Pol, H E
Hyde, C L
Isaev, D
Jablensky, A
Jansen, P R
Janssen, J
Jönsson, E G
Jung, L A
Kahn, R S
Kikinis, Z
Liu, K
Klauser, P
Knöchel, C
Kubicki, M
Lagopoulos, J
Langen, C
Lawrie, S
Lenroot, R K
Lim, K O
Lopez-Jaramillo, C
Lyall, A
Magnotta, V
Mandl, R C W
Mathalon, D H
McCarley, R W
McCarthy-Jones, S
McDonald, C
McEwen, S
McIntosh, A
Melicher, T
Mesholam-Gately, R I
Michie, P T
Mowry, B
Mueller, B A
Newell, D T
O'Donnell, P
Oertel-Knöchel, V
Oestreich, L
Paciga, S A
Pantelis, C
Pasternak, O
Pearlson, G
Pellicano, G R
Pereira, A
Pineda Zapata, J
Piras, F
Potkin, S G
Preda, A
Rasser, P E
Roalf, D R
Roiz, R
Roos, A
Rotenberg, D
Satterthwaite, T D
Savadjiev, P
Schall, U
Scott, R J
Seal, M L
Seidman, L J
Shannon Weickert, C
Whelan, C D
Shenton, M E
Kwon, J S
Spalletta, G
Spaniel, F
Sprooten, E
Stäblein, M
Stein, D J
Sundram, S
Tan, Y
Tan, S
Tang, S
Temmingh, H S
Westlye, L T
Tønnesen, S
Tordesillas-Gutierrez, D
Doan, N T
Vaidya, J
van Haren, N E M
Vargas, C D
Vecchio, D
Velakoulis, D
Voineskos, A
Voyvodic, J Q
Wang, Z
Wan, P
Wei, D
Weickert, T W
Whalley, H
White, T
Whitford, T J
Wojcik, J D
Xiang, H
Xie, Z
Yamamori, H
Yang, F
Yao, N
Zhang, G
Zhao, J
van Erp, T G M
Turner, J
Thompson, P M
Donohoe, G
author_sort Kelly, S
collection PubMed
description The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
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spelling pubmed-59840782018-06-04 Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group Kelly, S Jahanshad, N Zalesky, A Kochunov, P Agartz, I Alloza, C Andreassen, O A Arango, C Banaj, N Bouix, S Bousman, C A Brouwer, R M Bruggemann, J Bustillo, J Cahn, W Calhoun, V Cannon, D Carr, V Catts, S Chen, J Chen, J-x Chen, X Chiapponi, C Cho, Kl K Ciullo, V Corvin, A S Crespo-Facorro, B Cropley, V De Rossi, P Diaz-Caneja, C M Dickie, E W Ehrlich, S Fan, F-m Faskowitz, J Fatouros-Bergman, H Flyckt, L Ford, J M Fouche, J-P Fukunaga, M Gill, M Glahn, D C Gollub, R Goudzwaard, E D Guo, H Gur, R E Gur, R C Gurholt, T P Hashimoto, R Hatton, S N Henskens, F A Hibar, D P Hickie, I B Hong, L E Horacek, J Howells, F M Hulshoff Pol, H E Hyde, C L Isaev, D Jablensky, A Jansen, P R Janssen, J Jönsson, E G Jung, L A Kahn, R S Kikinis, Z Liu, K Klauser, P Knöchel, C Kubicki, M Lagopoulos, J Langen, C Lawrie, S Lenroot, R K Lim, K O Lopez-Jaramillo, C Lyall, A Magnotta, V Mandl, R C W Mathalon, D H McCarley, R W McCarthy-Jones, S McDonald, C McEwen, S McIntosh, A Melicher, T Mesholam-Gately, R I Michie, P T Mowry, B Mueller, B A Newell, D T O'Donnell, P Oertel-Knöchel, V Oestreich, L Paciga, S A Pantelis, C Pasternak, O Pearlson, G Pellicano, G R Pereira, A Pineda Zapata, J Piras, F Potkin, S G Preda, A Rasser, P E Roalf, D R Roiz, R Roos, A Rotenberg, D Satterthwaite, T D Savadjiev, P Schall, U Scott, R J Seal, M L Seidman, L J Shannon Weickert, C Whelan, C D Shenton, M E Kwon, J S Spalletta, G Spaniel, F Sprooten, E Stäblein, M Stein, D J Sundram, S Tan, Y Tan, S Tang, S Temmingh, H S Westlye, L T Tønnesen, S Tordesillas-Gutierrez, D Doan, N T Vaidya, J van Haren, N E M Vargas, C D Vecchio, D Velakoulis, D Voineskos, A Voyvodic, J Q Wang, Z Wan, P Wei, D Weickert, T W Whalley, H White, T Whitford, T J Wojcik, J D Xiang, H Xie, Z Yamamori, H Yang, F Yao, N Zhang, G Zhao, J van Erp, T G M Turner, J Thompson, P M Donohoe, G Mol Psychiatry Original Article The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org. Nature Publishing Group 2018-05 2017-10-17 /pmc/articles/PMC5984078/ /pubmed/29038599 http://dx.doi.org/10.1038/mp.2017.170 Text en Copyright © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Kelly, S
Jahanshad, N
Zalesky, A
Kochunov, P
Agartz, I
Alloza, C
Andreassen, O A
Arango, C
Banaj, N
Bouix, S
Bousman, C A
Brouwer, R M
Bruggemann, J
Bustillo, J
Cahn, W
Calhoun, V
Cannon, D
Carr, V
Catts, S
Chen, J
Chen, J-x
Chen, X
Chiapponi, C
Cho, Kl K
Ciullo, V
Corvin, A S
Crespo-Facorro, B
Cropley, V
De Rossi, P
Diaz-Caneja, C M
Dickie, E W
Ehrlich, S
Fan, F-m
Faskowitz, J
Fatouros-Bergman, H
Flyckt, L
Ford, J M
Fouche, J-P
Fukunaga, M
Gill, M
Glahn, D C
Gollub, R
Goudzwaard, E D
Guo, H
Gur, R E
Gur, R C
Gurholt, T P
Hashimoto, R
Hatton, S N
Henskens, F A
Hibar, D P
Hickie, I B
Hong, L E
Horacek, J
Howells, F M
Hulshoff Pol, H E
Hyde, C L
Isaev, D
Jablensky, A
Jansen, P R
Janssen, J
Jönsson, E G
Jung, L A
Kahn, R S
Kikinis, Z
Liu, K
Klauser, P
Knöchel, C
Kubicki, M
Lagopoulos, J
Langen, C
Lawrie, S
Lenroot, R K
Lim, K O
Lopez-Jaramillo, C
Lyall, A
Magnotta, V
Mandl, R C W
Mathalon, D H
McCarley, R W
McCarthy-Jones, S
McDonald, C
McEwen, S
McIntosh, A
Melicher, T
Mesholam-Gately, R I
Michie, P T
Mowry, B
Mueller, B A
Newell, D T
O'Donnell, P
Oertel-Knöchel, V
Oestreich, L
Paciga, S A
Pantelis, C
Pasternak, O
Pearlson, G
Pellicano, G R
Pereira, A
Pineda Zapata, J
Piras, F
Potkin, S G
Preda, A
Rasser, P E
Roalf, D R
Roiz, R
Roos, A
Rotenberg, D
Satterthwaite, T D
Savadjiev, P
Schall, U
Scott, R J
Seal, M L
Seidman, L J
Shannon Weickert, C
Whelan, C D
Shenton, M E
Kwon, J S
Spalletta, G
Spaniel, F
Sprooten, E
Stäblein, M
Stein, D J
Sundram, S
Tan, Y
Tan, S
Tang, S
Temmingh, H S
Westlye, L T
Tønnesen, S
Tordesillas-Gutierrez, D
Doan, N T
Vaidya, J
van Haren, N E M
Vargas, C D
Vecchio, D
Velakoulis, D
Voineskos, A
Voyvodic, J Q
Wang, Z
Wan, P
Wei, D
Weickert, T W
Whalley, H
White, T
Whitford, T J
Wojcik, J D
Xiang, H
Xie, Z
Yamamori, H
Yang, F
Yao, N
Zhang, G
Zhao, J
van Erp, T G M
Turner, J
Thompson, P M
Donohoe, G
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title_full Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title_fullStr Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title_full_unstemmed Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title_short Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
title_sort widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the enigma schizophrenia dti working group
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984078/
https://www.ncbi.nlm.nih.gov/pubmed/29038599
http://dx.doi.org/10.1038/mp.2017.170
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