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PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer

BACKGROUND: Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear. METHODS: To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistr...

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Autores principales: Heinrich, Marie-Christine, Göbel, Cosima, Kluth, Martina, Bernreuther, Christian, Sauer, Charlotte, Schroeder, Cornelia, Möller-Koop, Christina, Hube-Magg, Claudia, Lebok, Patrick, Burandt, Eike, Sauter, Guido, Simon, Ronald, Huland, Hartwig, Graefen, Markus, Heinzer, Hans, Schlomm, Thorsten, Heumann, Asmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984312/
https://www.ncbi.nlm.nih.gov/pubmed/29855276
http://dx.doi.org/10.1186/s12885-018-4547-7
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author Heinrich, Marie-Christine
Göbel, Cosima
Kluth, Martina
Bernreuther, Christian
Sauer, Charlotte
Schroeder, Cornelia
Möller-Koop, Christina
Hube-Magg, Claudia
Lebok, Patrick
Burandt, Eike
Sauter, Guido
Simon, Ronald
Huland, Hartwig
Graefen, Markus
Heinzer, Hans
Schlomm, Thorsten
Heumann, Asmus
author_facet Heinrich, Marie-Christine
Göbel, Cosima
Kluth, Martina
Bernreuther, Christian
Sauer, Charlotte
Schroeder, Cornelia
Möller-Koop, Christina
Hube-Magg, Claudia
Lebok, Patrick
Burandt, Eike
Sauter, Guido
Simon, Ronald
Huland, Hartwig
Graefen, Markus
Heinzer, Hans
Schlomm, Thorsten
Heumann, Asmus
author_sort Heinrich, Marie-Christine
collection PubMed
description BACKGROUND: Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear. METHODS: To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry. RESULTS: PSCA staining was absent in normal epithelial and stromal cells of the prostate. Membranous and cytoplasmic PSCA staining was seen in 53.7% of 9642 interpretable tumors. Staining was weak in 22.4%, moderate in 24.5% and strong in 6.8% of tumors. PSCA expression was associated with favorable pathological and clinical tumor features: Early pathological tumor stage (p < 0.0001), low Gleason grade (p < 0.0001), absence of lymph node metastasis (p < 0.0001), low pre-operative PSA level (p = 0.0118), negative surgical margin (p < 0.0001) and reduced PSA recurrence (p < 0.0001). PSCA expression was an independent predictor of prognosis in multivariate analysis (hazard ratio 0.84, p < 0.0001). CONCLUSIONS: The absence of statistical relationship to TMPRSS2:ERG fusion status, chromosomal deletion or high tumor cell proliferation argues against a major role of PSCA for regulation of cell cycle or genomic integrity. PSCA expression is linked to favorable prognosis. PSCA measurement is a candidate for inclusion in multi-parametric prognostic prostate cancer tests. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4547-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-59843122018-06-07 PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer Heinrich, Marie-Christine Göbel, Cosima Kluth, Martina Bernreuther, Christian Sauer, Charlotte Schroeder, Cornelia Möller-Koop, Christina Hube-Magg, Claudia Lebok, Patrick Burandt, Eike Sauter, Guido Simon, Ronald Huland, Hartwig Graefen, Markus Heinzer, Hans Schlomm, Thorsten Heumann, Asmus BMC Cancer Research Article BACKGROUND: Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear. METHODS: To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry. RESULTS: PSCA staining was absent in normal epithelial and stromal cells of the prostate. Membranous and cytoplasmic PSCA staining was seen in 53.7% of 9642 interpretable tumors. Staining was weak in 22.4%, moderate in 24.5% and strong in 6.8% of tumors. PSCA expression was associated with favorable pathological and clinical tumor features: Early pathological tumor stage (p < 0.0001), low Gleason grade (p < 0.0001), absence of lymph node metastasis (p < 0.0001), low pre-operative PSA level (p = 0.0118), negative surgical margin (p < 0.0001) and reduced PSA recurrence (p < 0.0001). PSCA expression was an independent predictor of prognosis in multivariate analysis (hazard ratio 0.84, p < 0.0001). CONCLUSIONS: The absence of statistical relationship to TMPRSS2:ERG fusion status, chromosomal deletion or high tumor cell proliferation argues against a major role of PSCA for regulation of cell cycle or genomic integrity. PSCA expression is linked to favorable prognosis. PSCA measurement is a candidate for inclusion in multi-parametric prognostic prostate cancer tests. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4547-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-31 /pmc/articles/PMC5984312/ /pubmed/29855276 http://dx.doi.org/10.1186/s12885-018-4547-7 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Heinrich, Marie-Christine
Göbel, Cosima
Kluth, Martina
Bernreuther, Christian
Sauer, Charlotte
Schroeder, Cornelia
Möller-Koop, Christina
Hube-Magg, Claudia
Lebok, Patrick
Burandt, Eike
Sauter, Guido
Simon, Ronald
Huland, Hartwig
Graefen, Markus
Heinzer, Hans
Schlomm, Thorsten
Heumann, Asmus
PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title_full PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title_fullStr PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title_full_unstemmed PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title_short PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
title_sort psca expression is associated with favorable tumor features and reduced psa recurrence in operated prostate cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984312/
https://www.ncbi.nlm.nih.gov/pubmed/29855276
http://dx.doi.org/10.1186/s12885-018-4547-7
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