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The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates

BACKGROUND: Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations....

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Autores principales: Alblooshi, Hiba, Hulse, Gary, Osman, Wael, El Kashef, Ahmed, Shawky, Mansour, Al Ghaferi, Hamad, Al Safar, Habiba, Tay, Guan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984335/
https://www.ncbi.nlm.nih.gov/pubmed/29881439
http://dx.doi.org/10.1186/s12991-018-0192-4
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author Alblooshi, Hiba
Hulse, Gary
Osman, Wael
El Kashef, Ahmed
Shawky, Mansour
Al Ghaferi, Hamad
Al Safar, Habiba
Tay, Guan K.
author_facet Alblooshi, Hiba
Hulse, Gary
Osman, Wael
El Kashef, Ahmed
Shawky, Mansour
Al Ghaferi, Hamad
Al Safar, Habiba
Tay, Guan K.
author_sort Alblooshi, Hiba
collection PubMed
description BACKGROUND: Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations. This study is the first study to determine the allele frequency and the genetic association of the DRD2 rs1076560 SNP and OPRM1 rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE). METHODS: A cross-sectional case–control cohort that consisted of 512 male subjects was studied. Two hundred and fifty patients with SUD receiving treatment at the UAE National Rehabilitation Center were compared to 262 controls with no prior history of mental health and SUD. DNA from each subject was extracted and genotyped using the TaqMan(®) SNP genotyping assay. RESULTS: There were no significant associations observed for DRD2 rs1076560 SNP, OPRM1 rs1799971 SNP, and combined genotypes of both SNPs in the SUD group. CONCLUSION: Further research is required with refinements to the criteria of the clinical phenotypes. Genetic studies have to be expanded to include other variants of the gene, the interaction with other genes, and possible epigenetic relationships.
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spelling pubmed-59843352018-06-07 The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates Alblooshi, Hiba Hulse, Gary Osman, Wael El Kashef, Ahmed Shawky, Mansour Al Ghaferi, Hamad Al Safar, Habiba Tay, Guan K. Ann Gen Psychiatry Primary Research BACKGROUND: Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations. This study is the first study to determine the allele frequency and the genetic association of the DRD2 rs1076560 SNP and OPRM1 rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE). METHODS: A cross-sectional case–control cohort that consisted of 512 male subjects was studied. Two hundred and fifty patients with SUD receiving treatment at the UAE National Rehabilitation Center were compared to 262 controls with no prior history of mental health and SUD. DNA from each subject was extracted and genotyped using the TaqMan(®) SNP genotyping assay. RESULTS: There were no significant associations observed for DRD2 rs1076560 SNP, OPRM1 rs1799971 SNP, and combined genotypes of both SNPs in the SUD group. CONCLUSION: Further research is required with refinements to the criteria of the clinical phenotypes. Genetic studies have to be expanded to include other variants of the gene, the interaction with other genes, and possible epigenetic relationships. BioMed Central 2018-06-01 /pmc/articles/PMC5984335/ /pubmed/29881439 http://dx.doi.org/10.1186/s12991-018-0192-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Primary Research
Alblooshi, Hiba
Hulse, Gary
Osman, Wael
El Kashef, Ahmed
Shawky, Mansour
Al Ghaferi, Hamad
Al Safar, Habiba
Tay, Guan K.
The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title_full The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title_fullStr The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title_full_unstemmed The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title_short The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
title_sort frequency of drd2 rs1076560 and oprm1 rs1799971 in substance use disorder patients from the united arab emirates
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984335/
https://www.ncbi.nlm.nih.gov/pubmed/29881439
http://dx.doi.org/10.1186/s12991-018-0192-4
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