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Association of plasma PCB levels and HbA1c concentration in Iran

BACKGROUND: The rapid increase in prevalence of diabetes mellitus over the last decades warrants more attention to the effects of environmental and occupational exposures on glucose metabolism. Our study aimed to assess the association between the plasma levels of various congeners of polychlorinate...

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Autores principales: Eftekhari, Sahar, Aminian, Omid, Moinfar, Zeinab, Schettgen, Thomas, Kaifie, Andrea, Felten, Michael, Kraus, Thomas, Esser, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984357/
https://www.ncbi.nlm.nih.gov/pubmed/29881441
http://dx.doi.org/10.1186/s12995-018-0199-4
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author Eftekhari, Sahar
Aminian, Omid
Moinfar, Zeinab
Schettgen, Thomas
Kaifie, Andrea
Felten, Michael
Kraus, Thomas
Esser, André
author_facet Eftekhari, Sahar
Aminian, Omid
Moinfar, Zeinab
Schettgen, Thomas
Kaifie, Andrea
Felten, Michael
Kraus, Thomas
Esser, André
author_sort Eftekhari, Sahar
collection PubMed
description BACKGROUND: The rapid increase in prevalence of diabetes mellitus over the last decades warrants more attention to the effects of environmental and occupational exposures on glucose metabolism. Our study aimed to assess the association between the plasma levels of various congeners of polychlorinated biphenyls (PCBs) and the serum concentration of glycated haemoglobin (HbA1c). METHODS: Our study population consisted of 140 Iranian adults from seven different occupational groups and a group of non-occupationally exposed female participants. The plasma concentration of PCBs were determined at the laboratory of occupational toxicology at RWTH Aachen University, Germany. We considered an HbA1c concentration of 5.7% and more as indicating a disturbed glucose metabolism. Logistic regression was used to assess the association between quartiles of concentrations of PCB congeners and serum HbA1c. RESULTS: Participants with an increased HbA1c value had higher plasma levels of PCB 138, 153, 180 and the PCB sum, although this association was statistically not significant. There was no significant difference between the levels of PCB 138, 153, 180, the sum of these congeners, and PCB 118 in their quartiles when comparing with HbA1c concentrations. CONCLUSIONS: For our cohort, we could not demonstrate a significant association between PCB and HbA1c concentrations indicating a disturbance of glucose metabolism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12995-018-0199-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-59843572018-06-07 Association of plasma PCB levels and HbA1c concentration in Iran Eftekhari, Sahar Aminian, Omid Moinfar, Zeinab Schettgen, Thomas Kaifie, Andrea Felten, Michael Kraus, Thomas Esser, André J Occup Med Toxicol Research BACKGROUND: The rapid increase in prevalence of diabetes mellitus over the last decades warrants more attention to the effects of environmental and occupational exposures on glucose metabolism. Our study aimed to assess the association between the plasma levels of various congeners of polychlorinated biphenyls (PCBs) and the serum concentration of glycated haemoglobin (HbA1c). METHODS: Our study population consisted of 140 Iranian adults from seven different occupational groups and a group of non-occupationally exposed female participants. The plasma concentration of PCBs were determined at the laboratory of occupational toxicology at RWTH Aachen University, Germany. We considered an HbA1c concentration of 5.7% and more as indicating a disturbed glucose metabolism. Logistic regression was used to assess the association between quartiles of concentrations of PCB congeners and serum HbA1c. RESULTS: Participants with an increased HbA1c value had higher plasma levels of PCB 138, 153, 180 and the PCB sum, although this association was statistically not significant. There was no significant difference between the levels of PCB 138, 153, 180, the sum of these congeners, and PCB 118 in their quartiles when comparing with HbA1c concentrations. CONCLUSIONS: For our cohort, we could not demonstrate a significant association between PCB and HbA1c concentrations indicating a disturbance of glucose metabolism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12995-018-0199-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-31 /pmc/articles/PMC5984357/ /pubmed/29881441 http://dx.doi.org/10.1186/s12995-018-0199-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Eftekhari, Sahar
Aminian, Omid
Moinfar, Zeinab
Schettgen, Thomas
Kaifie, Andrea
Felten, Michael
Kraus, Thomas
Esser, André
Association of plasma PCB levels and HbA1c concentration in Iran
title Association of plasma PCB levels and HbA1c concentration in Iran
title_full Association of plasma PCB levels and HbA1c concentration in Iran
title_fullStr Association of plasma PCB levels and HbA1c concentration in Iran
title_full_unstemmed Association of plasma PCB levels and HbA1c concentration in Iran
title_short Association of plasma PCB levels and HbA1c concentration in Iran
title_sort association of plasma pcb levels and hba1c concentration in iran
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984357/
https://www.ncbi.nlm.nih.gov/pubmed/29881441
http://dx.doi.org/10.1186/s12995-018-0199-4
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