The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology

Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian hom...

Descripción completa

Detalles Bibliográficos
Autores principales: Flynn, Benjamin P., Conway-Campbell, Becky L., Lightman, Stafford L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984398/
https://www.ncbi.nlm.nih.gov/pubmed/29627070
http://dx.doi.org/10.1016/j.ando.2018.03.003
Descripción
Sumario:Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian homeostatic rhythm, how its dysregulation effects glucocorticoid receptor and RNA polymeraseII recruitment and may play a significant role within aberrant metabolic action.

Ejemplares similares