Cargando…
Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti
The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984506/ https://www.ncbi.nlm.nih.gov/pubmed/29760098 http://dx.doi.org/10.1073/pnas.1720979115 |
_version_ | 1783328628823556096 |
---|---|
author | Motallebzadeh, Hamid Soons, Joris A. M. Puria, Sunil |
author_facet | Motallebzadeh, Hamid Soons, Joris A. M. Puria, Sunil |
author_sort | Motallebzadeh, Hamid |
collection | PubMed |
description | The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it turns out that other parts of the sensory epithelium closer to the IHCs, such as the reticular lamina (RL), move with significantly greater amplitude for weaker sounds. It has not been established how these findings are related to the complex cytoarchitecture of the organ of Corti between the BM and RL, which is composed of a lattice of asymmetric Y-shaped elements, each consisting of a basally slanted outer hair cell (OHC), an apically slanted phalangeal process (PhP), and a supporting Deiters’ cell (DC). Here, a computational model of the mouse cochlea supports the hypothesis that the OHC micromotors require this Y-shaped geometry for their contribution to the exquisite sensitivity and frequency selectivity of the mammalian cochlea. By varying only the OHC gain parameter, the model can reproduce measurements of BM and RL gain and tuning for a variety of input sound levels. Malformations such as reversing the orientations of the OHCs and PhPs or removing the PhPs altogether greatly reduce the effectiveness of the OHC motors. These results imply that the DCs and PhPs must be properly accounted for in emerging OHC regeneration therapies. |
format | Online Article Text |
id | pubmed-5984506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-59845062018-06-07 Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti Motallebzadeh, Hamid Soons, Joris A. M. Puria, Sunil Proc Natl Acad Sci U S A Biological Sciences The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it turns out that other parts of the sensory epithelium closer to the IHCs, such as the reticular lamina (RL), move with significantly greater amplitude for weaker sounds. It has not been established how these findings are related to the complex cytoarchitecture of the organ of Corti between the BM and RL, which is composed of a lattice of asymmetric Y-shaped elements, each consisting of a basally slanted outer hair cell (OHC), an apically slanted phalangeal process (PhP), and a supporting Deiters’ cell (DC). Here, a computational model of the mouse cochlea supports the hypothesis that the OHC micromotors require this Y-shaped geometry for their contribution to the exquisite sensitivity and frequency selectivity of the mammalian cochlea. By varying only the OHC gain parameter, the model can reproduce measurements of BM and RL gain and tuning for a variety of input sound levels. Malformations such as reversing the orientations of the OHCs and PhPs or removing the PhPs altogether greatly reduce the effectiveness of the OHC motors. These results imply that the DCs and PhPs must be properly accounted for in emerging OHC regeneration therapies. National Academy of Sciences 2018-05-29 2018-05-14 /pmc/articles/PMC5984506/ /pubmed/29760098 http://dx.doi.org/10.1073/pnas.1720979115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Motallebzadeh, Hamid Soons, Joris A. M. Puria, Sunil Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title | Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title_full | Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title_fullStr | Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title_full_unstemmed | Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title_short | Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti |
title_sort | cochlear amplification and tuning depend on the cellular arrangement within the organ of corti |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984506/ https://www.ncbi.nlm.nih.gov/pubmed/29760098 http://dx.doi.org/10.1073/pnas.1720979115 |
work_keys_str_mv | AT motallebzadehhamid cochlearamplificationandtuningdependonthecellulararrangementwithintheorganofcorti AT soonsjorisam cochlearamplificationandtuningdependonthecellulararrangementwithintheorganofcorti AT puriasunil cochlearamplificationandtuningdependonthecellulararrangementwithintheorganofcorti |