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Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue change...

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Autores principales: Hagemeier, Jesper, Zivadinov, Robert, Dwyer, Michael G., Polak, Paul, Bergsland, Niels, Weinstock-Guttman, Bianca, Zalis, Joshua, Deistung, Andreas, Reichenbach, Jürgen R., Schweser, Ferdinand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984575/
https://www.ncbi.nlm.nih.gov/pubmed/29868452
http://dx.doi.org/10.1016/j.nicl.2017.04.008
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author Hagemeier, Jesper
Zivadinov, Robert
Dwyer, Michael G.
Polak, Paul
Bergsland, Niels
Weinstock-Guttman, Bianca
Zalis, Joshua
Deistung, Andreas
Reichenbach, Jürgen R.
Schweser, Ferdinand
author_facet Hagemeier, Jesper
Zivadinov, Robert
Dwyer, Michael G.
Polak, Paul
Bergsland, Niels
Weinstock-Guttman, Bianca
Zalis, Joshua
Deistung, Andreas
Reichenbach, Jürgen R.
Schweser, Ferdinand
author_sort Hagemeier, Jesper
collection PubMed
description In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue changes associated with myelin loss and iron accumulation in multiple sclerosis deep gray matter (DGM) over two years. One-hundred twenty (120) multiple sclerosis patients and 40 age- and sex-matched healthy controls were included in this prospective study. Written informed consent and local IRB approval were obtained from all participants. Clinical testing and QSM were performed both at baseline and at follow-up. Brain magnetic susceptibility was measured in major DGM structures. Temporal (baseline vs. follow-up) and cross-sectional (multiple sclerosis vs. controls) differences were studied using mixed factorial ANOVA analysis and appropriate t-tests. At either time-point, multiple sclerosis patients had significantly higher susceptibility in the caudate and globus pallidus and lower susceptibility in the thalamus. Over two years, susceptibility increased significantly in the caudate of both controls and multiple sclerosis patients. Inverse thalamic findings among MS patients suggest a multi-phase pathology explained by simultaneous myelin loss and/or iron accumulation followed by iron depletion and/or calcium deposition at later stages.
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spelling pubmed-59845752018-06-04 Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain Hagemeier, Jesper Zivadinov, Robert Dwyer, Michael G. Polak, Paul Bergsland, Niels Weinstock-Guttman, Bianca Zalis, Joshua Deistung, Andreas Reichenbach, Jürgen R. Schweser, Ferdinand Neuroimage Clin Regular Article In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue changes associated with myelin loss and iron accumulation in multiple sclerosis deep gray matter (DGM) over two years. One-hundred twenty (120) multiple sclerosis patients and 40 age- and sex-matched healthy controls were included in this prospective study. Written informed consent and local IRB approval were obtained from all participants. Clinical testing and QSM were performed both at baseline and at follow-up. Brain magnetic susceptibility was measured in major DGM structures. Temporal (baseline vs. follow-up) and cross-sectional (multiple sclerosis vs. controls) differences were studied using mixed factorial ANOVA analysis and appropriate t-tests. At either time-point, multiple sclerosis patients had significantly higher susceptibility in the caudate and globus pallidus and lower susceptibility in the thalamus. Over two years, susceptibility increased significantly in the caudate of both controls and multiple sclerosis patients. Inverse thalamic findings among MS patients suggest a multi-phase pathology explained by simultaneous myelin loss and/or iron accumulation followed by iron depletion and/or calcium deposition at later stages. Elsevier 2017-04-13 /pmc/articles/PMC5984575/ /pubmed/29868452 http://dx.doi.org/10.1016/j.nicl.2017.04.008 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Hagemeier, Jesper
Zivadinov, Robert
Dwyer, Michael G.
Polak, Paul
Bergsland, Niels
Weinstock-Guttman, Bianca
Zalis, Joshua
Deistung, Andreas
Reichenbach, Jürgen R.
Schweser, Ferdinand
Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title_full Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title_fullStr Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title_full_unstemmed Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title_short Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
title_sort changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984575/
https://www.ncbi.nlm.nih.gov/pubmed/29868452
http://dx.doi.org/10.1016/j.nicl.2017.04.008
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