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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

BACKGROUND: The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer’s disease (AD), reflective of a central role for myeloid cells in neurodegeneration. Understanding how this variant confers AD risk promises to provide important insi...

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Detalles Bibliográficos
Autores principales:	Cheng-Hathaway, Paul J., Reed-Geaghan, Erin G., Jay, Taylor R., Casali, Brad T., Bemiller, Shane M., Puntambekar, Shweta S., von Saucken, Victoria E., Williams, Roxanne Y., Karlo, J. Colleen, Moutinho, Miguel, Xu, Guixiang, Ransohoff, Richard M., Lamb, Bruce T., Landreth, Gary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984804/ https://www.ncbi.nlm.nih.gov/pubmed/29859094 http://dx.doi.org/10.1186/s13024-018-0262-8

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