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How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels
Many have worked to create cardiac action potential models that explicitly represent atomic-level details of ion channel structure. Such models have the potential to define new therapeutic directions and to show how nanoscale perturbations to channel function predispose patients to deadly cardiac ar...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984968/ https://www.ncbi.nlm.nih.gov/pubmed/29401425 http://dx.doi.org/10.1016/j.bpj.2017.11.024 |
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author | Silva, Jonathan R. |
author_facet | Silva, Jonathan R. |
author_sort | Silva, Jonathan R. |
collection | PubMed |
description | Many have worked to create cardiac action potential models that explicitly represent atomic-level details of ion channel structure. Such models have the potential to define new therapeutic directions and to show how nanoscale perturbations to channel function predispose patients to deadly cardiac arrhythmia. However, there have been significant experimental and theoretical barriers that have limited model usefulness. Recently, many of these barriers have come down, suggesting that considerable progress toward creating these long-sought models may be possible in the near term. |
format | Online Article Text |
id | pubmed-5984968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Biophysical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-59849682019-01-23 How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels Silva, Jonathan R. Biophys J Biophysical Perspective Many have worked to create cardiac action potential models that explicitly represent atomic-level details of ion channel structure. Such models have the potential to define new therapeutic directions and to show how nanoscale perturbations to channel function predispose patients to deadly cardiac arrhythmia. However, there have been significant experimental and theoretical barriers that have limited model usefulness. Recently, many of these barriers have come down, suggesting that considerable progress toward creating these long-sought models may be possible in the near term. The Biophysical Society 2018-01-23 2018-02-03 /pmc/articles/PMC5984968/ /pubmed/29401425 http://dx.doi.org/10.1016/j.bpj.2017.11.024 Text en © 2017 Biophysical Society. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Biophysical Perspective Silva, Jonathan R. How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title | How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title_full | How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title_fullStr | How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title_full_unstemmed | How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title_short | How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels |
title_sort | how to connect cardiac excitation to the atomic interactions of ion channels |
topic | Biophysical Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984968/ https://www.ncbi.nlm.nih.gov/pubmed/29401425 http://dx.doi.org/10.1016/j.bpj.2017.11.024 |
work_keys_str_mv | AT silvajonathanr howtoconnectcardiacexcitationtotheatomicinteractionsofionchannels |