Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

OBJECTIVES: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms remains incomplete. Here, we aimed to determine the role of de novo ceramide synthesis in hypothalamus on the ons...

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Detalles Bibliográficos
Autores principales: Campana, Mélanie, Bellini, Lara, Rouch, Claude, Rachdi, Latif, Coant, Nicolas, Butin, Noémie, Bandet, Cécile L., Philippe, Erwann, Meneyrol, Kelly, Kassis, Nadim, Dairou, Julien, Hajduch, Eric, Colsch, Benoit, Magnan, Christophe, Le Stunff, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985020/
https://www.ncbi.nlm.nih.gov/pubmed/29233519
http://dx.doi.org/10.1016/j.molmet.2017.10.013

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