Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

OBJECTIVE: Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with low-dose doxorubicin, which is widely used to treat several types of cancer, may have beneficial effects on nonalcoholic fatty liv...

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Detalles Bibliográficos
Autores principales: Porteiro, Begoña, Fondevila, Marcos F., Buque, Xabier, Gonzalez-Rellan, Maria J., Fernandez, Uxia, Mora, Alfonso, Beiroa, Daniel, Senra, Ana, Gallego, Rosalia, Fernø, Johan, López, Miguel, Sabio, Guadalupe, Dieguez, Carlos, Aspichueta, Patricia, Nogueiras, Rubén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985045/
https://www.ncbi.nlm.nih.gov/pubmed/29290620
http://dx.doi.org/10.1016/j.molmet.2017.12.005

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