A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

OBJECTIVE: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons. As bile acids stimulate the release of FGF19/FGF1...

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Detalles Bibliográficos
Autores principales: Liu, Shunmei, Marcelin, Genevieve, Blouet, Clemence, Jeong, Jae Hoon, Jo, Young-Hwan, Schwartz, Gary J., Chua, Streamson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985052/
https://www.ncbi.nlm.nih.gov/pubmed/29290621
http://dx.doi.org/10.1016/j.molmet.2017.12.003

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