S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine

Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performe...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalal, Jamshed, Mohan, J. C., Iyengar, S. S., Hiremath, Jagdish, Sathyamurthy, Immaneni, Bansal, Sandeep, Kahali, Dhiman, Dasbiswas, Arup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985099/
https://www.ncbi.nlm.nih.gov/pubmed/29887996
http://dx.doi.org/10.1155/2018/8681792
_version_ 1783328705187151872
author Dalal, Jamshed
Mohan, J. C.
Iyengar, S. S.
Hiremath, Jagdish
Sathyamurthy, Immaneni
Bansal, Sandeep
Kahali, Dhiman
Dasbiswas, Arup
author_facet Dalal, Jamshed
Mohan, J. C.
Iyengar, S. S.
Hiremath, Jagdish
Sathyamurthy, Immaneni
Bansal, Sandeep
Kahali, Dhiman
Dasbiswas, Arup
author_sort Dalal, Jamshed
collection PubMed
description Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM. Efficacy and safety of S-AM in HTN in comparison to racemic amlodipine, used as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S-AM, are discussed in this review.
format Online
Article
Text
id pubmed-5985099
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59850992018-06-10 S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine Dalal, Jamshed Mohan, J. C. Iyengar, S. S. Hiremath, Jagdish Sathyamurthy, Immaneni Bansal, Sandeep Kahali, Dhiman Dasbiswas, Arup Int J Hypertens Review Article Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM. Efficacy and safety of S-AM in HTN in comparison to racemic amlodipine, used as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S-AM, are discussed in this review. Hindawi 2018-05-20 /pmc/articles/PMC5985099/ /pubmed/29887996 http://dx.doi.org/10.1155/2018/8681792 Text en Copyright © 2018 Jamshed Dalal et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dalal, Jamshed
Mohan, J. C.
Iyengar, S. S.
Hiremath, Jagdish
Sathyamurthy, Immaneni
Bansal, Sandeep
Kahali, Dhiman
Dasbiswas, Arup
S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title_full S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title_fullStr S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title_full_unstemmed S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title_short S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine
title_sort s-amlodipine: an isomer with difference—time to shift from racemic amlodipine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985099/
https://www.ncbi.nlm.nih.gov/pubmed/29887996
http://dx.doi.org/10.1155/2018/8681792
work_keys_str_mv AT dalaljamshed samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT mohanjc samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT iyengarss samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT hiremathjagdish samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT sathyamurthyimmaneni samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT bansalsandeep samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT kahalidhiman samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine
AT dasbiswasarup samlodipineanisomerwithdifferencetimetoshiftfromracemicamlodipine

Ejemplares similares