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Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy

Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis is an acinar cell inflammation, leading to “impaired autophagy flux”. Pancreatitis promotes acinar-to-ductal transdifferentiat...

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Detalles Bibliográficos
Autores principales:	Yasunaga, Kohei, Ito, Tetsuhide, Miki, Masami, Ueda, Keijiro, Fujiyama, Takashi, Tachibana, Yuichi, Fujimori, Nao, Kawabe, Ken, Ogawa, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985122/ https://www.ncbi.nlm.nih.gov/pubmed/29888283 http://dx.doi.org/10.1155/2018/8719397

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