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Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

OBJECTIVE: Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin sensitivity is important for disease management. Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal...

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Detalles Bibliográficos
Autores principales:	Hinke, Simon A., Cieniewicz, Anne M., Kirchner, Thomas, D'Aquino, Katharine, Nanjunda, Rupesh, Aligo, Jason, Perkinson, Robert, Cooper, Philip, Boayke, Ken, Chiu, Mark L., Jarantow, Steve, Lacy, Eilyn R., Liang, Yin, Johnson, Dana L., Whaley, Jean M., Lingham, Russell B., Kihm, Anthony J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985231/ https://www.ncbi.nlm.nih.gov/pubmed/29453154 http://dx.doi.org/10.1016/j.molmet.2018.01.014

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