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Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cya...

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Detalles Bibliográficos
Autores principales:	Albreht, Alen, Vovk, Irena, Mavri, Janez, Marco-Contelles, Jose, Ramsay, Rona R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985292/ https://www.ncbi.nlm.nih.gov/pubmed/29892597 http://dx.doi.org/10.3389/fchem.2018.00169

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