The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with...

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Autores principales: Donadon, Matteo, Lleo, Ana, Di Tommaso, Luca, Soldani, Cristiana, Franceschini, Barbara, Roncalli, Massimo, Torzilli, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985314/
https://www.ncbi.nlm.nih.gov/pubmed/29892573
http://dx.doi.org/10.3389/fonc.2018.00181
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author Donadon, Matteo
Lleo, Ana
Di Tommaso, Luca
Soldani, Cristiana
Franceschini, Barbara
Roncalli, Massimo
Torzilli, Guido
author_facet Donadon, Matteo
Lleo, Ana
Di Tommaso, Luca
Soldani, Cristiana
Franceschini, Barbara
Roncalli, Massimo
Torzilli, Guido
author_sort Donadon, Matteo
collection PubMed
description The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
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spelling pubmed-59853142018-06-11 The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors Donadon, Matteo Lleo, Ana Di Tommaso, Luca Soldani, Cristiana Franceschini, Barbara Roncalli, Massimo Torzilli, Guido Front Oncol Oncology The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system. Frontiers Media S.A. 2018-05-28 /pmc/articles/PMC5985314/ /pubmed/29892573 http://dx.doi.org/10.3389/fonc.2018.00181 Text en Copyright © 2018 Donadon, Lleo, Di Tommaso, Soldani, Franceschini, Roncalli and Torzilli. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Donadon, Matteo
Lleo, Ana
Di Tommaso, Luca
Soldani, Cristiana
Franceschini, Barbara
Roncalli, Massimo
Torzilli, Guido
The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title_full The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title_fullStr The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title_full_unstemmed The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title_short The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors
title_sort shifting paradigm of prognostic factors of colorectal liver metastases: from tumor-centered to host immune-centered factors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985314/
https://www.ncbi.nlm.nih.gov/pubmed/29892573
http://dx.doi.org/10.3389/fonc.2018.00181
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