Cargando…

Potential asbestos exposure among patients with primary lung cancer in Japan

OBJECTIVE: To investigate the extent of asbestos exposure among patients with primary lung cancer in Japan. METHODS: A retrospective estimation of potential asbestos-exposed individuals, as determined by the presence of pleural plaques identified on chest computed tomography (CT), was conducted on 8...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamura, Akihiko, Funakoshi, Mitsuhiko, J-P, Naw Awn, Hasegawa, Kichinori, Ishimine, Atsushi, Koike, Akio, Tannai, Noriyuki, Fujii, Masami, Hattori, Makoto, Hirano, Harukazu, Nakamura, Kenji, Funakoshi, Masanobu, Satomi, Kazuhiko, Yamashita, Yoshihito, Fukuchi, Yasuma, Suganuma, Narufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society for Occupational Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985347/
https://www.ncbi.nlm.nih.gov/pubmed/29563365
http://dx.doi.org/10.1539/joh.2017-0199-OA
_version_ 1783328744704835584
author Tamura, Akihiko
Funakoshi, Mitsuhiko
J-P, Naw Awn
Hasegawa, Kichinori
Ishimine, Atsushi
Koike, Akio
Tannai, Noriyuki
Fujii, Masami
Hattori, Makoto
Hirano, Harukazu
Nakamura, Kenji
Funakoshi, Masanobu
Satomi, Kazuhiko
Yamashita, Yoshihito
Fukuchi, Yasuma
Suganuma, Narufumi
author_facet Tamura, Akihiko
Funakoshi, Mitsuhiko
J-P, Naw Awn
Hasegawa, Kichinori
Ishimine, Atsushi
Koike, Akio
Tannai, Noriyuki
Fujii, Masami
Hattori, Makoto
Hirano, Harukazu
Nakamura, Kenji
Funakoshi, Masanobu
Satomi, Kazuhiko
Yamashita, Yoshihito
Fukuchi, Yasuma
Suganuma, Narufumi
author_sort Tamura, Akihiko
collection PubMed
description OBJECTIVE: To investigate the extent of asbestos exposure among patients with primary lung cancer in Japan. METHODS: A retrospective estimation of potential asbestos-exposed individuals, as determined by the presence of pleural plaques identified on chest computed tomography (CT), was conducted on 885 pathologically confirmed primary lung cancer patients (mean age 71.3 years, 641 males). All patients were diagnosed at 29 hospitals across Japan between 2006 and 2007. Since these hospitals belong to the Japan Federation of Democratic Medical Institutions (MIN-IREN), an organization of medical institutions for workers, the study subjects may contain a higher proportion of workers than the general population. RESULTS: Pleural plaques were identified in 12.8% of subjects (15.8% in males and 4.9% in females), consisting exclusively of cases older than 50 years. They were found most frequently on the chest wall pleura (96.5%), followed by the diaphragm (23.9%) and mediastinum (9.7%). Calcifications were seen in 47 cases (41.6%). The highest prevalence of pleural plaques was seen among workers from construction-related fields (37.7%). No distinct lung cancer histology was observed in patients with pleural plaques. Coexistence of pleural plaques and small irregular opacities was observed in 2.5% of subjects. CONCLUSION: In a Japanese population representing more workers than general Japanese, 12.8% of patients with primary lung cancer may have experienced asbestos exposure at some time in the past. Special medical attention should be paid to individuals with a history of employment in construction-related occupations, as workers in this sector showed the highest prevalence of pleural plaques.
format Online
Article
Text
id pubmed-5985347
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Japan Society for Occupational Health
record_format MEDLINE/PubMed
spelling pubmed-59853472018-06-06 Potential asbestos exposure among patients with primary lung cancer in Japan Tamura, Akihiko Funakoshi, Mitsuhiko J-P, Naw Awn Hasegawa, Kichinori Ishimine, Atsushi Koike, Akio Tannai, Noriyuki Fujii, Masami Hattori, Makoto Hirano, Harukazu Nakamura, Kenji Funakoshi, Masanobu Satomi, Kazuhiko Yamashita, Yoshihito Fukuchi, Yasuma Suganuma, Narufumi J Occup Health Original OBJECTIVE: To investigate the extent of asbestos exposure among patients with primary lung cancer in Japan. METHODS: A retrospective estimation of potential asbestos-exposed individuals, as determined by the presence of pleural plaques identified on chest computed tomography (CT), was conducted on 885 pathologically confirmed primary lung cancer patients (mean age 71.3 years, 641 males). All patients were diagnosed at 29 hospitals across Japan between 2006 and 2007. Since these hospitals belong to the Japan Federation of Democratic Medical Institutions (MIN-IREN), an organization of medical institutions for workers, the study subjects may contain a higher proportion of workers than the general population. RESULTS: Pleural plaques were identified in 12.8% of subjects (15.8% in males and 4.9% in females), consisting exclusively of cases older than 50 years. They were found most frequently on the chest wall pleura (96.5%), followed by the diaphragm (23.9%) and mediastinum (9.7%). Calcifications were seen in 47 cases (41.6%). The highest prevalence of pleural plaques was seen among workers from construction-related fields (37.7%). No distinct lung cancer histology was observed in patients with pleural plaques. Coexistence of pleural plaques and small irregular opacities was observed in 2.5% of subjects. CONCLUSION: In a Japanese population representing more workers than general Japanese, 12.8% of patients with primary lung cancer may have experienced asbestos exposure at some time in the past. Special medical attention should be paid to individuals with a history of employment in construction-related occupations, as workers in this sector showed the highest prevalence of pleural plaques. Japan Society for Occupational Health 2018-03-20 2018-05-20 /pmc/articles/PMC5985347/ /pubmed/29563365 http://dx.doi.org/10.1539/joh.2017-0199-OA Text en https://creativecommons.org/licenses/by-nc-sa/4.0/ Journal of Occupational Health is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original
Tamura, Akihiko
Funakoshi, Mitsuhiko
J-P, Naw Awn
Hasegawa, Kichinori
Ishimine, Atsushi
Koike, Akio
Tannai, Noriyuki
Fujii, Masami
Hattori, Makoto
Hirano, Harukazu
Nakamura, Kenji
Funakoshi, Masanobu
Satomi, Kazuhiko
Yamashita, Yoshihito
Fukuchi, Yasuma
Suganuma, Narufumi
Potential asbestos exposure among patients with primary lung cancer in Japan
title Potential asbestos exposure among patients with primary lung cancer in Japan
title_full Potential asbestos exposure among patients with primary lung cancer in Japan
title_fullStr Potential asbestos exposure among patients with primary lung cancer in Japan
title_full_unstemmed Potential asbestos exposure among patients with primary lung cancer in Japan
title_short Potential asbestos exposure among patients with primary lung cancer in Japan
title_sort potential asbestos exposure among patients with primary lung cancer in japan
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985347/
https://www.ncbi.nlm.nih.gov/pubmed/29563365
http://dx.doi.org/10.1539/joh.2017-0199-OA
work_keys_str_mv AT tamuraakihiko potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT funakoshimitsuhiko potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT jpnawawn potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT hasegawakichinori potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT ishimineatsushi potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT koikeakio potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT tannainoriyuki potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT fujiimasami potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT hattorimakoto potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT hiranoharukazu potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT nakamurakenji potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT funakoshimasanobu potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT satomikazuhiko potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT yamashitayoshihito potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT fukuchiyasuma potentialasbestosexposureamongpatientswithprimarylungcancerinjapan
AT suganumanarufumi potentialasbestosexposureamongpatientswithprimarylungcancerinjapan