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Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials

Following the original large-scale randomized trials of aspirin and β-blockade, there have been a number of major advances in pharmacological and mechanical treatments for acute myocardial infarction. Despite this progress, myocardial infarction remains a major global cause of mortality and morbidit...

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Autores principales: Spath, Nicholas B, Mills, Nicholas L, Cruden, Nicholas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985502/
https://www.ncbi.nlm.nih.gov/pubmed/27791385
http://dx.doi.org/10.2217/fca-2016-0044
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author Spath, Nicholas B
Mills, Nicholas L
Cruden, Nicholas L
author_facet Spath, Nicholas B
Mills, Nicholas L
Cruden, Nicholas L
author_sort Spath, Nicholas B
collection PubMed
description Following the original large-scale randomized trials of aspirin and β-blockade, there have been a number of major advances in pharmacological and mechanical treatments for acute myocardial infarction. Despite this progress, myocardial infarction remains a major global cause of mortality and morbidity, driving a quest for novel treatments in this area. As the understanding of mitochondrial dynamics and the pathophysiology of reperfusion injury has evolved, the last three decades have seen advances in ischemic conditioning, pharmacological and metabolic cardioprotection, as well as biological and stem-cell therapies. The aim of this review is to provide a synopsis of adjunctive cardioprotective and regenerative therapies currently undergoing or entering early clinical trials in the treatment of patients with acute myocardial infarction.
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spelling pubmed-59855022018-06-05 Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials Spath, Nicholas B Mills, Nicholas L Cruden, Nicholas L Future Cardiol Review Following the original large-scale randomized trials of aspirin and β-blockade, there have been a number of major advances in pharmacological and mechanical treatments for acute myocardial infarction. Despite this progress, myocardial infarction remains a major global cause of mortality and morbidity, driving a quest for novel treatments in this area. As the understanding of mitochondrial dynamics and the pathophysiology of reperfusion injury has evolved, the last three decades have seen advances in ischemic conditioning, pharmacological and metabolic cardioprotection, as well as biological and stem-cell therapies. The aim of this review is to provide a synopsis of adjunctive cardioprotective and regenerative therapies currently undergoing or entering early clinical trials in the treatment of patients with acute myocardial infarction. Future Medicine Ltd 2016-11 2016-10-28 /pmc/articles/PMC5985502/ /pubmed/27791385 http://dx.doi.org/10.2217/fca-2016-0044 Text en © 2016 Nicholas B Spath This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Spath, Nicholas B
Mills, Nicholas L
Cruden, Nicholas L
Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title_full Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title_fullStr Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title_full_unstemmed Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title_short Novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
title_sort novel cardioprotective and regenerative therapies in acute myocardial infarction: a review of recent and ongoing clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985502/
https://www.ncbi.nlm.nih.gov/pubmed/27791385
http://dx.doi.org/10.2217/fca-2016-0044
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