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Breast Cancer Immunotherapy: An Update

The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology commu...

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Detalles Bibliográficos
Autores principales: Makhoul, Issam, Atiq, Mohammad, Alwbari, Ahmed, Kieber-Emmons, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550/
https://www.ncbi.nlm.nih.gov/pubmed/29899661
http://dx.doi.org/10.1177/1178223418774802
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author Makhoul, Issam
Atiq, Mohammad
Alwbari, Ahmed
Kieber-Emmons, Thomas
author_facet Makhoul, Issam
Atiq, Mohammad
Alwbari, Ahmed
Kieber-Emmons, Thomas
author_sort Makhoul, Issam
collection PubMed
description The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community’s interest in extending the benefits to all cancers including breast cancer. The first section of this article reviews the biological foundations of the immune response to different subtypes of breast cancer and the ways cancer may overcome the immune attack leading to cancer disease. The second section is dedicated to the actual immune treatments including breast cancer vaccines, checkpoint inhibitors, monoclonal antibodies, and the “unconventional” immune role of chemotherapy.
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spelling pubmed-59855502018-06-13 Breast Cancer Immunotherapy: An Update Makhoul, Issam Atiq, Mohammad Alwbari, Ahmed Kieber-Emmons, Thomas Breast Cancer (Auckl) Review The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community’s interest in extending the benefits to all cancers including breast cancer. The first section of this article reviews the biological foundations of the immune response to different subtypes of breast cancer and the ways cancer may overcome the immune attack leading to cancer disease. The second section is dedicated to the actual immune treatments including breast cancer vaccines, checkpoint inhibitors, monoclonal antibodies, and the “unconventional” immune role of chemotherapy. SAGE Publications 2018-05-30 /pmc/articles/PMC5985550/ /pubmed/29899661 http://dx.doi.org/10.1177/1178223418774802 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Makhoul, Issam
Atiq, Mohammad
Alwbari, Ahmed
Kieber-Emmons, Thomas
Breast Cancer Immunotherapy: An Update
title Breast Cancer Immunotherapy: An Update
title_full Breast Cancer Immunotherapy: An Update
title_fullStr Breast Cancer Immunotherapy: An Update
title_full_unstemmed Breast Cancer Immunotherapy: An Update
title_short Breast Cancer Immunotherapy: An Update
title_sort breast cancer immunotherapy: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550/
https://www.ncbi.nlm.nih.gov/pubmed/29899661
http://dx.doi.org/10.1177/1178223418774802
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