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Breast Cancer Immunotherapy: An Update
The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology commu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550/ https://www.ncbi.nlm.nih.gov/pubmed/29899661 http://dx.doi.org/10.1177/1178223418774802 |
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author | Makhoul, Issam Atiq, Mohammad Alwbari, Ahmed Kieber-Emmons, Thomas |
author_facet | Makhoul, Issam Atiq, Mohammad Alwbari, Ahmed Kieber-Emmons, Thomas |
author_sort | Makhoul, Issam |
collection | PubMed |
description | The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community’s interest in extending the benefits to all cancers including breast cancer. The first section of this article reviews the biological foundations of the immune response to different subtypes of breast cancer and the ways cancer may overcome the immune attack leading to cancer disease. The second section is dedicated to the actual immune treatments including breast cancer vaccines, checkpoint inhibitors, monoclonal antibodies, and the “unconventional” immune role of chemotherapy. |
format | Online Article Text |
id | pubmed-5985550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59855502018-06-13 Breast Cancer Immunotherapy: An Update Makhoul, Issam Atiq, Mohammad Alwbari, Ahmed Kieber-Emmons, Thomas Breast Cancer (Auckl) Review The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community’s interest in extending the benefits to all cancers including breast cancer. The first section of this article reviews the biological foundations of the immune response to different subtypes of breast cancer and the ways cancer may overcome the immune attack leading to cancer disease. The second section is dedicated to the actual immune treatments including breast cancer vaccines, checkpoint inhibitors, monoclonal antibodies, and the “unconventional” immune role of chemotherapy. SAGE Publications 2018-05-30 /pmc/articles/PMC5985550/ /pubmed/29899661 http://dx.doi.org/10.1177/1178223418774802 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Makhoul, Issam Atiq, Mohammad Alwbari, Ahmed Kieber-Emmons, Thomas Breast Cancer Immunotherapy: An Update |
title | Breast Cancer Immunotherapy: An Update |
title_full | Breast Cancer Immunotherapy: An Update |
title_fullStr | Breast Cancer Immunotherapy: An Update |
title_full_unstemmed | Breast Cancer Immunotherapy: An Update |
title_short | Breast Cancer Immunotherapy: An Update |
title_sort | breast cancer immunotherapy: an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550/ https://www.ncbi.nlm.nih.gov/pubmed/29899661 http://dx.doi.org/10.1177/1178223418774802 |
work_keys_str_mv | AT makhoulissam breastcancerimmunotherapyanupdate AT atiqmohammad breastcancerimmunotherapyanupdate AT alwbariahmed breastcancerimmunotherapyanupdate AT kieberemmonsthomas breastcancerimmunotherapyanupdate |