A rare case of atypical/anaplastic meningioma with MDM2 amplification

We report the exceptional occurrence of murine double minute clone 2 amplification in an atypical meningioma and its recurrent anaplastic meningioma arising in the right frontal lobe of a 75-year-old man. Murine double minute clone 2 amplification was shown by array comparative genomic hybridization...

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Detalles Bibliográficos
Autores principales: Wylleman, Robbert, Debiec-Rychter, Maria, Sciot, Raf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985599/
https://www.ncbi.nlm.nih.gov/pubmed/29899887
http://dx.doi.org/10.1177/2036361318779511
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author Wylleman, Robbert
Debiec-Rychter, Maria
Sciot, Raf
author_facet Wylleman, Robbert
Debiec-Rychter, Maria
Sciot, Raf
author_sort Wylleman, Robbert
collection PubMed
description We report the exceptional occurrence of murine double minute clone 2 amplification in an atypical meningioma and its recurrent anaplastic meningioma arising in the right frontal lobe of a 75-year-old man. Murine double minute clone 2 amplification was shown by array comparative genomic hybridization and confirmed by fluorescence in situ hybridization. This is a rare finding with only one similar report in the literature. Awareness of this finding is indicated and should not lead to misdiagnosis of other entities that more commonly show this feature.
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spelling pubmed-59855992018-06-13 A rare case of atypical/anaplastic meningioma with MDM2 amplification Wylleman, Robbert Debiec-Rychter, Maria Sciot, Raf Rare Tumors Case Report We report the exceptional occurrence of murine double minute clone 2 amplification in an atypical meningioma and its recurrent anaplastic meningioma arising in the right frontal lobe of a 75-year-old man. Murine double minute clone 2 amplification was shown by array comparative genomic hybridization and confirmed by fluorescence in situ hybridization. This is a rare finding with only one similar report in the literature. Awareness of this finding is indicated and should not lead to misdiagnosis of other entities that more commonly show this feature. SAGE Publications 2018-05-31 /pmc/articles/PMC5985599/ /pubmed/29899887 http://dx.doi.org/10.1177/2036361318779511 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Wylleman, Robbert
Debiec-Rychter, Maria
Sciot, Raf
A rare case of atypical/anaplastic meningioma with MDM2 amplification
title A rare case of atypical/anaplastic meningioma with MDM2 amplification
title_full A rare case of atypical/anaplastic meningioma with MDM2 amplification
title_fullStr A rare case of atypical/anaplastic meningioma with MDM2 amplification
title_full_unstemmed A rare case of atypical/anaplastic meningioma with MDM2 amplification
title_short A rare case of atypical/anaplastic meningioma with MDM2 amplification
title_sort rare case of atypical/anaplastic meningioma with mdm2 amplification
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985599/
https://www.ncbi.nlm.nih.gov/pubmed/29899887
http://dx.doi.org/10.1177/2036361318779511
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