Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons

The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different genes encode the mitochondrial and cytosolic forms of most other tRNA synthetases. Dominant GARS mutations were described in inherited neuropathies,...

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Detalles Bibliográficos
Autores principales: Boczonadi, Veronika, Meyer, Kathrin, Gonczarowska-Jorge, Humberto, Griffin, Helen, Roos, Andreas, Bartsakoulia, Marina, Bansagi, Boglarka, Ricci, Giulia, Palinkas, Fanni, Zahedi, René P, Bruni, Francesco, Kaspar, Brian, Lochmüller, Hanns, Boycott, Kym M, Müller, Juliane S, Horvath, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985729/
https://www.ncbi.nlm.nih.gov/pubmed/29648643
http://dx.doi.org/10.1093/hmg/ddy127

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