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Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells
[Image: see text] T cells expressing tumor-specific T cell receptors are promising cancer therapeutic agents, but safety control switches are needed to manage potential side effects arising from overactivity. Here, we present the first dual small molecule-gated ZAP70 signaling switch for the regulat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985775/ https://www.ncbi.nlm.nih.gov/pubmed/29589904 http://dx.doi.org/10.1021/acssynbio.7b00394 |