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Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells

[Image: see text] T cells expressing tumor-specific T cell receptors are promising cancer therapeutic agents, but safety control switches are needed to manage potential side effects arising from overactivity. Here, we present the first dual small molecule-gated ZAP70 signaling switch for the regulat...

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Detalles Bibliográficos
Autores principales:	Wong, Nicole M. L., Wong, Wilson W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985775/ https://www.ncbi.nlm.nih.gov/pubmed/29589904 http://dx.doi.org/10.1021/acssynbio.7b00394

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