Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs...

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Detalles Bibliográficos
Autores principales: Pollak, Nina M., Hoffman, Matthew, Goldberg, Ira J., Drosatos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
STATE-OF-THE-ART REVIEW
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985828/
https://www.ncbi.nlm.nih.gov/pubmed/29876529
http://dx.doi.org/10.1016/j.jacbts.2017.09.001
Descripción
Sumario:Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.

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