Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs...

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Detalles Bibliográficos
Autores principales: Pollak, Nina M., Hoffman, Matthew, Goldberg, Ira J., Drosatos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
STATE-OF-THE-ART REVIEW
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985828/
https://www.ncbi.nlm.nih.gov/pubmed/29876529
http://dx.doi.org/10.1016/j.jacbts.2017.09.001
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author Pollak, Nina M.
Hoffman, Matthew
Goldberg, Ira J.
Drosatos, Konstantinos
author_facet Pollak, Nina M.
Hoffman, Matthew
Goldberg, Ira J.
Drosatos, Konstantinos
author_sort Pollak, Nina M.
collection PubMed
description Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.
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spelling pubmed-59858282018-06-04 Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways Pollak, Nina M. Hoffman, Matthew Goldberg, Ira J. Drosatos, Konstantinos JACC Basic Transl Sci STATE-OF-THE-ART REVIEW Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease. Elsevier 2018-03-01 /pmc/articles/PMC5985828/ /pubmed/29876529 http://dx.doi.org/10.1016/j.jacbts.2017.09.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle STATE-OF-THE-ART REVIEW
Pollak, Nina M.
Hoffman, Matthew
Goldberg, Ira J.
Drosatos, Konstantinos
Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title_full Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title_fullStr Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title_full_unstemmed Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title_short Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
title_sort krüppel-like factors: crippling and uncrippling metabolic pathways
topic STATE-OF-THE-ART REVIEW
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985828/
https://www.ncbi.nlm.nih.gov/pubmed/29876529
http://dx.doi.org/10.1016/j.jacbts.2017.09.001
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