The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers. METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia. RESULTS:...

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Detalles Bibliográficos
Autores principales: Soeroso, Noni Novisari, Zain-Hamid, Rozaimah, Sinaga, Bintang Y. M., Sadewa, Ahmad Hamim, Syafiuddin, Tamsil, Syahruddin, Elisna, Tann, Gino, Mutiara, Erna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985876/
https://www.ncbi.nlm.nih.gov/pubmed/29875862
http://dx.doi.org/10.3889/oamjms.2018.224
Descripción
Sumario:AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers. METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia. RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index. CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.

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