The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers. METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia. RESULTS:...

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Autores principales: Soeroso, Noni Novisari, Zain-Hamid, Rozaimah, Sinaga, Bintang Y. M., Sadewa, Ahmad Hamim, Syafiuddin, Tamsil, Syahruddin, Elisna, Tann, Gino, Mutiara, Erna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985876/
https://www.ncbi.nlm.nih.gov/pubmed/29875862
http://dx.doi.org/10.3889/oamjms.2018.224
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author Soeroso, Noni Novisari
Zain-Hamid, Rozaimah
Sinaga, Bintang Y. M.
Sadewa, Ahmad Hamim
Syafiuddin, Tamsil
Syahruddin, Elisna
Tann, Gino
Mutiara, Erna
author_facet Soeroso, Noni Novisari
Zain-Hamid, Rozaimah
Sinaga, Bintang Y. M.
Sadewa, Ahmad Hamim
Syafiuddin, Tamsil
Syahruddin, Elisna
Tann, Gino
Mutiara, Erna
author_sort Soeroso, Noni Novisari
collection PubMed
description AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers. METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia. RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index. CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.
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spelling pubmed-59858762018-06-06 The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers Soeroso, Noni Novisari Zain-Hamid, Rozaimah Sinaga, Bintang Y. M. Sadewa, Ahmad Hamim Syafiuddin, Tamsil Syahruddin, Elisna Tann, Gino Mutiara, Erna Open Access Maced J Med Sci Brief Communication AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers. METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia. RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index. CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants. Republic of Macedonia 2018-05-19 /pmc/articles/PMC5985876/ /pubmed/29875862 http://dx.doi.org/10.3889/oamjms.2018.224 Text en Copyright: © 2018 Noni Novisari Soeroso, Rozaimah Zain-Hamid, Bintang Y. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Brief Communication
Soeroso, Noni Novisari
Zain-Hamid, Rozaimah
Sinaga, Bintang Y. M.
Sadewa, Ahmad Hamim
Syafiuddin, Tamsil
Syahruddin, Elisna
Tann, Gino
Mutiara, Erna
The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title_full The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title_fullStr The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title_full_unstemmed The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title_short The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
title_sort role of cyp2a6 genetic polymorphism in nicotine dependence and tobacco consumption among bataknese male smokers
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985876/
https://www.ncbi.nlm.nih.gov/pubmed/29875862
http://dx.doi.org/10.3889/oamjms.2018.224
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