A disconnect between precursor frequency, expansion potential, and site-specific CD4(+) T cell responses in aged mice

T cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naïve CD4(+) and CD8(+) T cells declines. However, unlike for CD8(+) T cells, there are more naïve and memory phenotype CD...

Descripción completa

Detalles Bibliográficos
Autores principales: Deshpande, Neha R., Uhrlaub, Jennifer L., Way, Sing Sing, Nikolich-Žugich, Janko, Kuhns, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986155/
https://www.ncbi.nlm.nih.gov/pubmed/29864157
http://dx.doi.org/10.1371/journal.pone.0198354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986155/
https://www.ncbi.nlm.nih.gov/pubmed/29864157
http://dx.doi.org/10.1371/journal.pone.0198354

Ejemplares similares