Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca(2+) sensitivity and calpain-induced proteolysis

The acceleration of myocardial relaxation produced by β-adrenoreceptor stimulation is mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac troponin-I (cTnI), which decreases myofibrillar Ca(2+) sensitivity. Previous evidence suggests that phosphorylation of both Ser-23 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin-Garrido, Abel, Biesiadecki, Brandon J., Salhi, Hussam E., Shaifta, Yasin, dos Remedios, Cristobal G., Ayaz-Guner, Serife, Cai, Wenxuan, Ge, Ying, Avkiran, Metin, Kentish, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986213/
https://www.ncbi.nlm.nih.gov/pubmed/29669813
http://dx.doi.org/10.1074/jbc.RA117.001292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986213/
https://www.ncbi.nlm.nih.gov/pubmed/29669813
http://dx.doi.org/10.1074/jbc.RA117.001292

Ejemplares similares