Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

CTCF and cohesin are key drivers of 3D-nuclear organization, anchoring the megabase-scale Topologically Associating Domains (TADs) that segment the genome. Here, we present and validate a computational method to predict cohesin-and-CTCF binding sites that form intra-TAD DNA loops. The intra-TAD loop...

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Detalles Bibliográficos
Autores principales: Matthews, Bryan J, Waxman, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986275/
https://www.ncbi.nlm.nih.gov/pubmed/29757144
http://dx.doi.org/10.7554/eLife.34077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986275/
https://www.ncbi.nlm.nih.gov/pubmed/29757144
http://dx.doi.org/10.7554/eLife.34077

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