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Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia

Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lacto...

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Autores principales: Baldan, Alessandro, Tagliati, Sylvie, Saccomandi, Daniela, Brusaferro, Andrea, Busoli, Laura, Scala, Andrea, Malaventura, Cristina, Maggiore, Giuseppe, Borgna-Pignatti, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986438/
https://www.ncbi.nlm.nih.gov/pubmed/29723971
http://dx.doi.org/10.3390/nu10050558
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author Baldan, Alessandro
Tagliati, Sylvie
Saccomandi, Daniela
Brusaferro, Andrea
Busoli, Laura
Scala, Andrea
Malaventura, Cristina
Maggiore, Giuseppe
Borgna-Pignatti, Caterina
author_facet Baldan, Alessandro
Tagliati, Sylvie
Saccomandi, Daniela
Brusaferro, Andrea
Busoli, Laura
Scala, Andrea
Malaventura, Cristina
Maggiore, Giuseppe
Borgna-Pignatti, Caterina
author_sort Baldan, Alessandro
collection PubMed
description Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lactose-free diet on the bone mineral status (BMS), we compared the phalangeal BMS of adolescents with ATH to that of peers on a normal diet. Also, we analyzed the correlations between BMS and dietary behavior, physical exercise, and calcium and vitamin D intake. A total of 102 cases and 102 healthy controls filled out a diet record and underwent phalangeal Quantitative Ultrasound (QUS). No difference in BMS was observed. The time spent on lactose-free diet (4.8 ± 3.1 years) was inversely correlated to the BMS. More than 98% of cases consumed lactose-free milk, but calcium and vitamin D intake were significantly lower. Calcium intake was correlated to physical exercise but not to BMS. Our results suggest that a lactose-free diet does not affect the phalangeal BMS of adolescents with primary lactase deficiency when their diet includes lactose-free cow’s milk. However, there is still a significantly lower calcium intake than in the population reference. The inverse correlation observed between the BMS and the time spent on a lactose-free diet suggests that a long-term follow-up is advisable.
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spelling pubmed-59864382018-06-05 Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia Baldan, Alessandro Tagliati, Sylvie Saccomandi, Daniela Brusaferro, Andrea Busoli, Laura Scala, Andrea Malaventura, Cristina Maggiore, Giuseppe Borgna-Pignatti, Caterina Nutrients Article Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lactose-free diet on the bone mineral status (BMS), we compared the phalangeal BMS of adolescents with ATH to that of peers on a normal diet. Also, we analyzed the correlations between BMS and dietary behavior, physical exercise, and calcium and vitamin D intake. A total of 102 cases and 102 healthy controls filled out a diet record and underwent phalangeal Quantitative Ultrasound (QUS). No difference in BMS was observed. The time spent on lactose-free diet (4.8 ± 3.1 years) was inversely correlated to the BMS. More than 98% of cases consumed lactose-free milk, but calcium and vitamin D intake were significantly lower. Calcium intake was correlated to physical exercise but not to BMS. Our results suggest that a lactose-free diet does not affect the phalangeal BMS of adolescents with primary lactase deficiency when their diet includes lactose-free cow’s milk. However, there is still a significantly lower calcium intake than in the population reference. The inverse correlation observed between the BMS and the time spent on a lactose-free diet suggests that a long-term follow-up is advisable. MDPI 2018-05-01 /pmc/articles/PMC5986438/ /pubmed/29723971 http://dx.doi.org/10.3390/nu10050558 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baldan, Alessandro
Tagliati, Sylvie
Saccomandi, Daniela
Brusaferro, Andrea
Busoli, Laura
Scala, Andrea
Malaventura, Cristina
Maggiore, Giuseppe
Borgna-Pignatti, Caterina
Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title_full Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title_fullStr Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title_full_unstemmed Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title_short Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia
title_sort assessment of lactose-free diet on the phalangeal bone mineral status in italian adolescents affected by adult-type hypolactasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986438/
https://www.ncbi.nlm.nih.gov/pubmed/29723971
http://dx.doi.org/10.3390/nu10050558
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