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Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986445/ https://www.ncbi.nlm.nih.gov/pubmed/29734675 http://dx.doi.org/10.3390/nu10050565 |
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author | Guillén-Enríquez, Carolina Lopez-Teros, Veronica Martín-Orozco, Ubicelio López-Díaz, José A. del Hierro-Ochoa, Julio Ramos-Jiménez, Arnulfo Astiazarán-García, Humberto Martínez-Ruiz, Nina del Rocío Wall-Medrano, Abraham |
author_facet | Guillén-Enríquez, Carolina Lopez-Teros, Veronica Martín-Orozco, Ubicelio López-Díaz, José A. del Hierro-Ochoa, Julio Ramos-Jiménez, Arnulfo Astiazarán-García, Humberto Martínez-Ruiz, Nina del Rocío Wall-Medrano, Abraham |
author_sort | Guillén-Enríquez, Carolina |
collection | PubMed |
description | Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, dietary intake, body fat distribution, and histological and biochemical parameters were recorded. Compared to control rats, non-supplemented and supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35–52 g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. The HF+ diet was associated with the best anti-adiposity effect (as measured with the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the testes were observed. The results indicate that GGG is more effective when co-administered with HF diets in obese rats. |
format | Online Article Text |
id | pubmed-5986445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59864452018-06-05 Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets Guillén-Enríquez, Carolina Lopez-Teros, Veronica Martín-Orozco, Ubicelio López-Díaz, José A. del Hierro-Ochoa, Julio Ramos-Jiménez, Arnulfo Astiazarán-García, Humberto Martínez-Ruiz, Nina del Rocío Wall-Medrano, Abraham Nutrients Article Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, dietary intake, body fat distribution, and histological and biochemical parameters were recorded. Compared to control rats, non-supplemented and supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35–52 g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. The HF+ diet was associated with the best anti-adiposity effect (as measured with the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the testes were observed. The results indicate that GGG is more effective when co-administered with HF diets in obese rats. MDPI 2018-05-04 /pmc/articles/PMC5986445/ /pubmed/29734675 http://dx.doi.org/10.3390/nu10050565 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guillén-Enríquez, Carolina Lopez-Teros, Veronica Martín-Orozco, Ubicelio López-Díaz, José A. del Hierro-Ochoa, Julio Ramos-Jiménez, Arnulfo Astiazarán-García, Humberto Martínez-Ruiz, Nina del Rocío Wall-Medrano, Abraham Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title | Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title_full | Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title_fullStr | Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title_full_unstemmed | Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title_short | Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets |
title_sort | selected physiological effects of a garcinia gummi-gutta extract in rats fed with different hypercaloric diets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986445/ https://www.ncbi.nlm.nih.gov/pubmed/29734675 http://dx.doi.org/10.3390/nu10050565 |
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