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Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets

Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for...

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Autores principales: Guillén-Enríquez, Carolina, Lopez-Teros, Veronica, Martín-Orozco, Ubicelio, López-Díaz, José A., del Hierro-Ochoa, Julio, Ramos-Jiménez, Arnulfo, Astiazarán-García, Humberto, Martínez-Ruiz, Nina del Rocío, Wall-Medrano, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986445/
https://www.ncbi.nlm.nih.gov/pubmed/29734675
http://dx.doi.org/10.3390/nu10050565
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author Guillén-Enríquez, Carolina
Lopez-Teros, Veronica
Martín-Orozco, Ubicelio
López-Díaz, José A.
del Hierro-Ochoa, Julio
Ramos-Jiménez, Arnulfo
Astiazarán-García, Humberto
Martínez-Ruiz, Nina del Rocío
Wall-Medrano, Abraham
author_facet Guillén-Enríquez, Carolina
Lopez-Teros, Veronica
Martín-Orozco, Ubicelio
López-Díaz, José A.
del Hierro-Ochoa, Julio
Ramos-Jiménez, Arnulfo
Astiazarán-García, Humberto
Martínez-Ruiz, Nina del Rocío
Wall-Medrano, Abraham
author_sort Guillén-Enríquez, Carolina
collection PubMed
description Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, dietary intake, body fat distribution, and histological and biochemical parameters were recorded. Compared to control rats, non-supplemented and supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35–52 g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. The HF+ diet was associated with the best anti-adiposity effect (as measured with the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the testes were observed. The results indicate that GGG is more effective when co-administered with HF diets in obese rats.
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spelling pubmed-59864452018-06-05 Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets Guillén-Enríquez, Carolina Lopez-Teros, Veronica Martín-Orozco, Ubicelio López-Díaz, José A. del Hierro-Ochoa, Julio Ramos-Jiménez, Arnulfo Astiazarán-García, Humberto Martínez-Ruiz, Nina del Rocío Wall-Medrano, Abraham Nutrients Article Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, dietary intake, body fat distribution, and histological and biochemical parameters were recorded. Compared to control rats, non-supplemented and supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35–52 g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. The HF+ diet was associated with the best anti-adiposity effect (as measured with the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the testes were observed. The results indicate that GGG is more effective when co-administered with HF diets in obese rats. MDPI 2018-05-04 /pmc/articles/PMC5986445/ /pubmed/29734675 http://dx.doi.org/10.3390/nu10050565 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guillén-Enríquez, Carolina
Lopez-Teros, Veronica
Martín-Orozco, Ubicelio
López-Díaz, José A.
del Hierro-Ochoa, Julio
Ramos-Jiménez, Arnulfo
Astiazarán-García, Humberto
Martínez-Ruiz, Nina del Rocío
Wall-Medrano, Abraham
Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title_full Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title_fullStr Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title_full_unstemmed Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title_short Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with Different Hypercaloric Diets
title_sort selected physiological effects of a garcinia gummi-gutta extract in rats fed with different hypercaloric diets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986445/
https://www.ncbi.nlm.nih.gov/pubmed/29734675
http://dx.doi.org/10.3390/nu10050565
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