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Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study
There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss. Obesity and T2DM are also associated with increased inflammation. Mangosteen is a tropic...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986466/ https://www.ncbi.nlm.nih.gov/pubmed/29747432 http://dx.doi.org/10.3390/nu10050586 |
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author | Watanabe, Mikiko Gangitano, Elena Francomano, Davide Addessi, Eliana Toscano, Raffaella Costantini, Daniela Tuccinardi, Dario Mariani, Stefania Basciani, Sabrina Spera, Giovanni Gnessi, Lucio Lubrano, Carla |
author_facet | Watanabe, Mikiko Gangitano, Elena Francomano, Davide Addessi, Eliana Toscano, Raffaella Costantini, Daniela Tuccinardi, Dario Mariani, Stefania Basciani, Sabrina Spera, Giovanni Gnessi, Lucio Lubrano, Carla |
author_sort | Watanabe, Mikiko |
collection | PubMed |
description | There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss. Obesity and T2DM are also associated with increased inflammation. Mangosteen is a tropical tree, whose fruits—known for their antioxidant properties—have been recently suggested having a possible further role in the treatment of obesity and T2DM. The objective of this pilot study has been to evaluate safety and efficacy of treatment with mangosteen extract on insulin resistance, weight management, and inflammatory status in obese female patients with insulin resistance. Twenty-two patients were randomized 1:1 to behavioral therapy alone or behavioral therapy and mangosteen and 20 completed the 26-week study. The mangosteen group reported a significant improvement in insulin sensitivity (homeostatic model assessment-insulin resistance, HOMA-IR −53.22% vs. −15.23%, p = 0.004), and no side effect attributable to treatment was reported. Given the positive preliminary results we report and the excellent safety profile, we suggest a possible supplementary role of mangosteen extracts in the treatment of obesity, insulin resistance, and inflammation. |
format | Online Article Text |
id | pubmed-5986466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59864662018-06-05 Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study Watanabe, Mikiko Gangitano, Elena Francomano, Davide Addessi, Eliana Toscano, Raffaella Costantini, Daniela Tuccinardi, Dario Mariani, Stefania Basciani, Sabrina Spera, Giovanni Gnessi, Lucio Lubrano, Carla Nutrients Article There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss. Obesity and T2DM are also associated with increased inflammation. Mangosteen is a tropical tree, whose fruits—known for their antioxidant properties—have been recently suggested having a possible further role in the treatment of obesity and T2DM. The objective of this pilot study has been to evaluate safety and efficacy of treatment with mangosteen extract on insulin resistance, weight management, and inflammatory status in obese female patients with insulin resistance. Twenty-two patients were randomized 1:1 to behavioral therapy alone or behavioral therapy and mangosteen and 20 completed the 26-week study. The mangosteen group reported a significant improvement in insulin sensitivity (homeostatic model assessment-insulin resistance, HOMA-IR −53.22% vs. −15.23%, p = 0.004), and no side effect attributable to treatment was reported. Given the positive preliminary results we report and the excellent safety profile, we suggest a possible supplementary role of mangosteen extracts in the treatment of obesity, insulin resistance, and inflammation. MDPI 2018-05-09 /pmc/articles/PMC5986466/ /pubmed/29747432 http://dx.doi.org/10.3390/nu10050586 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Watanabe, Mikiko Gangitano, Elena Francomano, Davide Addessi, Eliana Toscano, Raffaella Costantini, Daniela Tuccinardi, Dario Mariani, Stefania Basciani, Sabrina Spera, Giovanni Gnessi, Lucio Lubrano, Carla Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title | Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title_full | Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title_fullStr | Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title_full_unstemmed | Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title_short | Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study |
title_sort | mangosteen extract shows a potent insulin sensitizing effect in obese female patients: a prospective randomized controlled pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986466/ https://www.ncbi.nlm.nih.gov/pubmed/29747432 http://dx.doi.org/10.3390/nu10050586 |
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