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Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability

Phospholipids (PL) or partial acylglycerols such as sn-1(3)-monoacylglycerol (MAG) are potent dietary carriers of long-chain polyunsaturated fatty acids (LC-PUFA) and have been reported to provide superior bioavailability when compared to conventional triacylglycerol (TAG). The main objective of the...

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Autores principales: Destaillats, Frédéric, Oliveira, Manuel, Bastic Schmid, Viktoria, Masserey-Elmelegy, Isabelle, Giuffrida, Francesca, Thakkar, Sagar K., Dupuis, Lénaïck, Gosoniu, Maria Laura, Cruz-Hernandez, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986500/
https://www.ncbi.nlm.nih.gov/pubmed/29762503
http://dx.doi.org/10.3390/nu10050620
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author Destaillats, Frédéric
Oliveira, Manuel
Bastic Schmid, Viktoria
Masserey-Elmelegy, Isabelle
Giuffrida, Francesca
Thakkar, Sagar K.
Dupuis, Lénaïck
Gosoniu, Maria Laura
Cruz-Hernandez, Cristina
author_facet Destaillats, Frédéric
Oliveira, Manuel
Bastic Schmid, Viktoria
Masserey-Elmelegy, Isabelle
Giuffrida, Francesca
Thakkar, Sagar K.
Dupuis, Lénaïck
Gosoniu, Maria Laura
Cruz-Hernandez, Cristina
author_sort Destaillats, Frédéric
collection PubMed
description Phospholipids (PL) or partial acylglycerols such as sn-1(3)-monoacylglycerol (MAG) are potent dietary carriers of long-chain polyunsaturated fatty acids (LC-PUFA) and have been reported to provide superior bioavailability when compared to conventional triacylglycerol (TAG). The main objective of the present study was to compare the incorporation of docosahexaenoic acid (DHA) in plasma, erythrocytes, retina and brain tissues in adult rats when provided as PL (PL-DHA) and MAG (MAG-DHA). Conventional dietary DHA oil containing TAG (TAG-DHA) as well as control chow diet were used to evaluate the potency of the two alternative DHA carriers over a 60-day feeding period. Fatty acid profiles were determined in erythrocytes and plasma lipids at time 0, 7, 14, 28, 35 and 49 days of the experimental period and in retina, cortex, hypothalamus, and hippocampus at 60 days. The assessment of the longitudinal evolution of DHA in erythrocyte and plasma lipids suggest that PL-DHA and MAG-DHA are efficient carriers of dietary DHA when compared to conventional DHA oil (TAG-DHA). Under these experimental conditions, both PL-DHA and MAG-DHA led to higher incorporations of DHA erythrocytes lipids compared to TAG-DHA group. After 60 days of supplementation, statistically significant increase in DHA level incorporated in neural tissues analyzed were observed in the DHA groups compared with the control. The mechanism explaining hypothetically the difference observed in circulatory lipids is discussed.
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spelling pubmed-59865002018-06-05 Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability Destaillats, Frédéric Oliveira, Manuel Bastic Schmid, Viktoria Masserey-Elmelegy, Isabelle Giuffrida, Francesca Thakkar, Sagar K. Dupuis, Lénaïck Gosoniu, Maria Laura Cruz-Hernandez, Cristina Nutrients Article Phospholipids (PL) or partial acylglycerols such as sn-1(3)-monoacylglycerol (MAG) are potent dietary carriers of long-chain polyunsaturated fatty acids (LC-PUFA) and have been reported to provide superior bioavailability when compared to conventional triacylglycerol (TAG). The main objective of the present study was to compare the incorporation of docosahexaenoic acid (DHA) in plasma, erythrocytes, retina and brain tissues in adult rats when provided as PL (PL-DHA) and MAG (MAG-DHA). Conventional dietary DHA oil containing TAG (TAG-DHA) as well as control chow diet were used to evaluate the potency of the two alternative DHA carriers over a 60-day feeding period. Fatty acid profiles were determined in erythrocytes and plasma lipids at time 0, 7, 14, 28, 35 and 49 days of the experimental period and in retina, cortex, hypothalamus, and hippocampus at 60 days. The assessment of the longitudinal evolution of DHA in erythrocyte and plasma lipids suggest that PL-DHA and MAG-DHA are efficient carriers of dietary DHA when compared to conventional DHA oil (TAG-DHA). Under these experimental conditions, both PL-DHA and MAG-DHA led to higher incorporations of DHA erythrocytes lipids compared to TAG-DHA group. After 60 days of supplementation, statistically significant increase in DHA level incorporated in neural tissues analyzed were observed in the DHA groups compared with the control. The mechanism explaining hypothetically the difference observed in circulatory lipids is discussed. MDPI 2018-05-15 /pmc/articles/PMC5986500/ /pubmed/29762503 http://dx.doi.org/10.3390/nu10050620 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Destaillats, Frédéric
Oliveira, Manuel
Bastic Schmid, Viktoria
Masserey-Elmelegy, Isabelle
Giuffrida, Francesca
Thakkar, Sagar K.
Dupuis, Lénaïck
Gosoniu, Maria Laura
Cruz-Hernandez, Cristina
Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title_full Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title_fullStr Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title_full_unstemmed Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title_short Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
title_sort comparison of the incorporation of dha in circulatory and neural tissue when provided as triacylglycerol (tag), monoacylglycerol (mag) or phospholipids (pl) provides new insight into fatty acid bioavailability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986500/
https://www.ncbi.nlm.nih.gov/pubmed/29762503
http://dx.doi.org/10.3390/nu10050620
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