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Iron Status and Gestational Diabetes—A Meta-Analysis

A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies (N = 44,110) published in 200...

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Autores principales: Kataria, Yachana, Wu, Yanxin, Horskjær, Peter de Hemmer, Mandrup-Poulsen, Thomas, Ellervik, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986501/
https://www.ncbi.nlm.nih.gov/pubmed/29762515
http://dx.doi.org/10.3390/nu10050621
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author Kataria, Yachana
Wu, Yanxin
Horskjær, Peter de Hemmer
Mandrup-Poulsen, Thomas
Ellervik, Christina
author_facet Kataria, Yachana
Wu, Yanxin
Horskjær, Peter de Hemmer
Mandrup-Poulsen, Thomas
Ellervik, Christina
author_sort Kataria, Yachana
collection PubMed
description A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies (N = 44,110) published in 2001–2017. The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 µg/dL (95% CI: 0.001–0.50) for iron, 1.54 ng/mL (0.56–2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40–1.22) for hemoglobin. Adjusted odds ratio for GDM were 1.58 (95% CI: 1.20–2.08) for ferritin, 1.30 (1.01–1.67) for hemoglobin, and 1.48 (1.29–1.69) for dietary heme intake. We did not find any differences in TIBC or transferrin concentration in women with and without GDM. We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. Considerable heterogeneity was present among the studies (0–99%), but no evidence of publication bias. Accumulating evidence suggests that circulating and dietary iron biomarkers among pregnant women are associated with GDM, but the results should be interpreted with caution due to the high heterogeneity of analyses. Randomized trials investigating the benefits of iron reduction in women at high risk for GDM are warranted.
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spelling pubmed-59865012018-06-05 Iron Status and Gestational Diabetes—A Meta-Analysis Kataria, Yachana Wu, Yanxin Horskjær, Peter de Hemmer Mandrup-Poulsen, Thomas Ellervik, Christina Nutrients Review A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies (N = 44,110) published in 2001–2017. The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 µg/dL (95% CI: 0.001–0.50) for iron, 1.54 ng/mL (0.56–2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40–1.22) for hemoglobin. Adjusted odds ratio for GDM were 1.58 (95% CI: 1.20–2.08) for ferritin, 1.30 (1.01–1.67) for hemoglobin, and 1.48 (1.29–1.69) for dietary heme intake. We did not find any differences in TIBC or transferrin concentration in women with and without GDM. We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. Considerable heterogeneity was present among the studies (0–99%), but no evidence of publication bias. Accumulating evidence suggests that circulating and dietary iron biomarkers among pregnant women are associated with GDM, but the results should be interpreted with caution due to the high heterogeneity of analyses. Randomized trials investigating the benefits of iron reduction in women at high risk for GDM are warranted. MDPI 2018-05-15 /pmc/articles/PMC5986501/ /pubmed/29762515 http://dx.doi.org/10.3390/nu10050621 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kataria, Yachana
Wu, Yanxin
Horskjær, Peter de Hemmer
Mandrup-Poulsen, Thomas
Ellervik, Christina
Iron Status and Gestational Diabetes—A Meta-Analysis
title Iron Status and Gestational Diabetes—A Meta-Analysis
title_full Iron Status and Gestational Diabetes—A Meta-Analysis
title_fullStr Iron Status and Gestational Diabetes—A Meta-Analysis
title_full_unstemmed Iron Status and Gestational Diabetes—A Meta-Analysis
title_short Iron Status and Gestational Diabetes—A Meta-Analysis
title_sort iron status and gestational diabetes—a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986501/
https://www.ncbi.nlm.nih.gov/pubmed/29762515
http://dx.doi.org/10.3390/nu10050621
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