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Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excreti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986503/ https://www.ncbi.nlm.nih.gov/pubmed/29772642 http://dx.doi.org/10.3390/nu10050624 |
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author | Margolis, Lee M. Ceglia, Lisa Rivas, Donato A. Dawson-Hughes, Bess Fielding, Roger A. |
author_facet | Margolis, Lee M. Ceglia, Lisa Rivas, Donato A. Dawson-Hughes, Bess Fielding, Roger A. |
author_sort | Margolis, Lee M. |
collection | PubMed |
description | With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO(3); n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day(−1)) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase. KHCO(3) or PLA supplementation began during energy restriction. NAE, NBAL, and whole-body ammonia and urea turnover ((15)N-glycine) were measured at the end of the weight-maintenance and energy-restriction phases. Following energy restriction, NAE was −9.8 ± 27.8 mmol∙day(−1) in KHCO(3) and 43.9 ± 27.8 mmol∙day(−1) in PLA (p < 0.05). No significant group or time differences were observed in NBAL or ammonia and urea turnover. Ammonia synthesis and breakdown tended (p = 0.09) to be higher in KHCO(3) vs. PLA following energy restriction, and NAE was inversely associated (r = −0.522; p < 0.05) with urea synthesis in all subjects. This pilot study suggests some benefit may exist with KHCO(3) supplementation following energy restriction as lower NAE indicated higher urea synthesis. |
format | Online Article Text |
id | pubmed-5986503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59865032018-06-05 Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men Margolis, Lee M. Ceglia, Lisa Rivas, Donato A. Dawson-Hughes, Bess Fielding, Roger A. Nutrients Article With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO(3); n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day(−1)) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase. KHCO(3) or PLA supplementation began during energy restriction. NAE, NBAL, and whole-body ammonia and urea turnover ((15)N-glycine) were measured at the end of the weight-maintenance and energy-restriction phases. Following energy restriction, NAE was −9.8 ± 27.8 mmol∙day(−1) in KHCO(3) and 43.9 ± 27.8 mmol∙day(−1) in PLA (p < 0.05). No significant group or time differences were observed in NBAL or ammonia and urea turnover. Ammonia synthesis and breakdown tended (p = 0.09) to be higher in KHCO(3) vs. PLA following energy restriction, and NAE was inversely associated (r = −0.522; p < 0.05) with urea synthesis in all subjects. This pilot study suggests some benefit may exist with KHCO(3) supplementation following energy restriction as lower NAE indicated higher urea synthesis. MDPI 2018-05-16 /pmc/articles/PMC5986503/ /pubmed/29772642 http://dx.doi.org/10.3390/nu10050624 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Margolis, Lee M. Ceglia, Lisa Rivas, Donato A. Dawson-Hughes, Bess Fielding, Roger A. Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title | Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title_full | Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title_fullStr | Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title_full_unstemmed | Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title_short | Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men |
title_sort | pilot study examining the influence of potassium bicarbonate supplementation on nitrogen balance and whole-body ammonia and urea turnover following short-term energy restriction in older men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986503/ https://www.ncbi.nlm.nih.gov/pubmed/29772642 http://dx.doi.org/10.3390/nu10050624 |
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