Cargando…

Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men

With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excreti...

Descripción completa

Detalles Bibliográficos
Autores principales: Margolis, Lee M., Ceglia, Lisa, Rivas, Donato A., Dawson-Hughes, Bess, Fielding, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986503/
https://www.ncbi.nlm.nih.gov/pubmed/29772642
http://dx.doi.org/10.3390/nu10050624
_version_ 1783328938477486080
author Margolis, Lee M.
Ceglia, Lisa
Rivas, Donato A.
Dawson-Hughes, Bess
Fielding, Roger A.
author_facet Margolis, Lee M.
Ceglia, Lisa
Rivas, Donato A.
Dawson-Hughes, Bess
Fielding, Roger A.
author_sort Margolis, Lee M.
collection PubMed
description With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO(3); n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day(−1)) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase. KHCO(3) or PLA supplementation began during energy restriction. NAE, NBAL, and whole-body ammonia and urea turnover ((15)N-glycine) were measured at the end of the weight-maintenance and energy-restriction phases. Following energy restriction, NAE was −9.8 ± 27.8 mmol∙day(−1) in KHCO(3) and 43.9 ± 27.8 mmol∙day(−1) in PLA (p < 0.05). No significant group or time differences were observed in NBAL or ammonia and urea turnover. Ammonia synthesis and breakdown tended (p = 0.09) to be higher in KHCO(3) vs. PLA following energy restriction, and NAE was inversely associated (r = −0.522; p < 0.05) with urea synthesis in all subjects. This pilot study suggests some benefit may exist with KHCO(3) supplementation following energy restriction as lower NAE indicated higher urea synthesis.
format Online
Article
Text
id pubmed-5986503
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59865032018-06-05 Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men Margolis, Lee M. Ceglia, Lisa Rivas, Donato A. Dawson-Hughes, Bess Fielding, Roger A. Nutrients Article With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day(−1) potassium bicarbonate (KHCO(3)) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO(3); n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day(−1)) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase. KHCO(3) or PLA supplementation began during energy restriction. NAE, NBAL, and whole-body ammonia and urea turnover ((15)N-glycine) were measured at the end of the weight-maintenance and energy-restriction phases. Following energy restriction, NAE was −9.8 ± 27.8 mmol∙day(−1) in KHCO(3) and 43.9 ± 27.8 mmol∙day(−1) in PLA (p < 0.05). No significant group or time differences were observed in NBAL or ammonia and urea turnover. Ammonia synthesis and breakdown tended (p = 0.09) to be higher in KHCO(3) vs. PLA following energy restriction, and NAE was inversely associated (r = −0.522; p < 0.05) with urea synthesis in all subjects. This pilot study suggests some benefit may exist with KHCO(3) supplementation following energy restriction as lower NAE indicated higher urea synthesis. MDPI 2018-05-16 /pmc/articles/PMC5986503/ /pubmed/29772642 http://dx.doi.org/10.3390/nu10050624 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Margolis, Lee M.
Ceglia, Lisa
Rivas, Donato A.
Dawson-Hughes, Bess
Fielding, Roger A.
Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title_full Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title_fullStr Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title_full_unstemmed Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title_short Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men
title_sort pilot study examining the influence of potassium bicarbonate supplementation on nitrogen balance and whole-body ammonia and urea turnover following short-term energy restriction in older men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986503/
https://www.ncbi.nlm.nih.gov/pubmed/29772642
http://dx.doi.org/10.3390/nu10050624
work_keys_str_mv AT margolisleem pilotstudyexaminingtheinfluenceofpotassiumbicarbonatesupplementationonnitrogenbalanceandwholebodyammoniaandureaturnoverfollowingshorttermenergyrestrictioninoldermen
AT ceglialisa pilotstudyexaminingtheinfluenceofpotassiumbicarbonatesupplementationonnitrogenbalanceandwholebodyammoniaandureaturnoverfollowingshorttermenergyrestrictioninoldermen
AT rivasdonatoa pilotstudyexaminingtheinfluenceofpotassiumbicarbonatesupplementationonnitrogenbalanceandwholebodyammoniaandureaturnoverfollowingshorttermenergyrestrictioninoldermen
AT dawsonhughesbess pilotstudyexaminingtheinfluenceofpotassiumbicarbonatesupplementationonnitrogenbalanceandwholebodyammoniaandureaturnoverfollowingshorttermenergyrestrictioninoldermen
AT fieldingrogera pilotstudyexaminingtheinfluenceofpotassiumbicarbonatesupplementationonnitrogenbalanceandwholebodyammoniaandureaturnoverfollowingshorttermenergyrestrictioninoldermen