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A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs

The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic aci...

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Autores principales: Buddington, Randal K., Chizhikov, Victor V., Iskusnykh, Igor Y., Sable, Helen J., Sable, Jeffrey J., Holloway, Zade R., Blumenfeld Katzir, Tamar, van der Merwe, Marie, Yakimkova, Taisiya, Buddington, Karyl K., Lifshitz, Yael, Tessler, Shoshi, Gilbert, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986516/
https://www.ncbi.nlm.nih.gov/pubmed/29783637
http://dx.doi.org/10.3390/nu10050637
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author Buddington, Randal K.
Chizhikov, Victor V.
Iskusnykh, Igor Y.
Sable, Helen J.
Sable, Jeffrey J.
Holloway, Zade R.
Blumenfeld Katzir, Tamar
van der Merwe, Marie
Yakimkova, Taisiya
Buddington, Karyl K.
Lifshitz, Yael
Tessler, Shoshi
Gilbert, Ariel
author_facet Buddington, Randal K.
Chizhikov, Victor V.
Iskusnykh, Igor Y.
Sable, Helen J.
Sable, Jeffrey J.
Holloway, Zade R.
Blumenfeld Katzir, Tamar
van der Merwe, Marie
Yakimkova, Taisiya
Buddington, Karyl K.
Lifshitz, Yael
Tessler, Shoshi
Gilbert, Ariel
author_sort Buddington, Randal K.
collection PubMed
description The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic acid (DHA), are considered of particular importance, results from clinical trials with preterm infants have been inconclusive because of ethical limitations and confounding variables. A translational large animal model is needed to understand the structural and functional responses to DHA. Neurodevelopment of preterm pigs was evaluated in response to feeding formulas to term-equivalent age supplemented with DHA attached to phosphatidylserine (PS-DHA) or sunflower oil as the placebo. Newborn term pigs were used as a control for normal in utero neurodevelopment. Supplementing formula with PS-DHA increased weight of the brain, and particularly the cerebellum, at term-equivalent age compared with placebo preterm pigs (P’s < 0.10 and 0.05 respectively), with a higher degree of myelination in all regions of the brain examined (all p < 0.06). Brains of pigs provided PS-DHA were similar in weight to newborn term pigs. Event-related brain potentials and performance in a novel object recognition test indicated the PS-DHA supplement accelerated development of sensory pathways and recognition memory compared with placebo preterm pigs. The PS-DHA did not increase weight gain, but was associated with higher survival. The benefits of PS-DHA include improving neurodevelopment and possibly improvement of survival, and justify further studies to define dose-response relations, compare benefits associated with other sources of DHA, and understand the mechanisms underlying the benefits and influences on the development of other tissues and organ systems.
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spelling pubmed-59865162018-06-05 A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs Buddington, Randal K. Chizhikov, Victor V. Iskusnykh, Igor Y. Sable, Helen J. Sable, Jeffrey J. Holloway, Zade R. Blumenfeld Katzir, Tamar van der Merwe, Marie Yakimkova, Taisiya Buddington, Karyl K. Lifshitz, Yael Tessler, Shoshi Gilbert, Ariel Nutrients Article The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic acid (DHA), are considered of particular importance, results from clinical trials with preterm infants have been inconclusive because of ethical limitations and confounding variables. A translational large animal model is needed to understand the structural and functional responses to DHA. Neurodevelopment of preterm pigs was evaluated in response to feeding formulas to term-equivalent age supplemented with DHA attached to phosphatidylserine (PS-DHA) or sunflower oil as the placebo. Newborn term pigs were used as a control for normal in utero neurodevelopment. Supplementing formula with PS-DHA increased weight of the brain, and particularly the cerebellum, at term-equivalent age compared with placebo preterm pigs (P’s < 0.10 and 0.05 respectively), with a higher degree of myelination in all regions of the brain examined (all p < 0.06). Brains of pigs provided PS-DHA were similar in weight to newborn term pigs. Event-related brain potentials and performance in a novel object recognition test indicated the PS-DHA supplement accelerated development of sensory pathways and recognition memory compared with placebo preterm pigs. The PS-DHA did not increase weight gain, but was associated with higher survival. The benefits of PS-DHA include improving neurodevelopment and possibly improvement of survival, and justify further studies to define dose-response relations, compare benefits associated with other sources of DHA, and understand the mechanisms underlying the benefits and influences on the development of other tissues and organ systems. MDPI 2018-05-18 /pmc/articles/PMC5986516/ /pubmed/29783637 http://dx.doi.org/10.3390/nu10050637 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buddington, Randal K.
Chizhikov, Victor V.
Iskusnykh, Igor Y.
Sable, Helen J.
Sable, Jeffrey J.
Holloway, Zade R.
Blumenfeld Katzir, Tamar
van der Merwe, Marie
Yakimkova, Taisiya
Buddington, Karyl K.
Lifshitz, Yael
Tessler, Shoshi
Gilbert, Ariel
A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title_full A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title_fullStr A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title_full_unstemmed A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title_short A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs
title_sort phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986516/
https://www.ncbi.nlm.nih.gov/pubmed/29783637
http://dx.doi.org/10.3390/nu10050637
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