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Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42)

Oxidized cholesterol has been widely reported to contribute to the pathogenesis of Alzheimer's disease (AD). However, the mechanism by which they affect the disease is not fully understood. Herein, we aimed to investigate the effect of 7-ketocholesterol (7keto) on membrane-mediated aggregation...

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Detalles Bibliográficos
Autores principales: Phan, Huong T.T., Shimokawa, Naofumi, Sharma, Neha, Takagi, Masahiro, Vestergaard, Mun'delanji C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986554/
https://www.ncbi.nlm.nih.gov/pubmed/29872741
http://dx.doi.org/10.1016/j.bbrep.2018.04.007

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