Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL) patients and compared it to non-high-risk APL cases. Despite the lack of common genetic signatures, we found that human hrAPL blasts from patient...

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Detalles Bibliográficos
Autores principales: Singh, Abhishek A., Petraglia, Francesca, Nebbioso, Angela, Yi, Guoqiang, Conte, Mariarosaria, Valente, Sergio, Mandoli, Amit, Scisciola, Lucia, Lindeboom, Rik, Kerstens, Hinri, Janssen-Megens, Eva M., Pourfarzad, Farzin, Habibi, Ehsan, Berentsen, Kim, Kim, Bowon, Logie, Colin, Heath, Simon, Wierenga, Albertus T.J., Clarke, Laura, Flicek, Paul, Jansen, Joop H., Kuijpers, Taco, Yaspo, Marie Laure, Valle, Veronique Della, Bernard, Olivier, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Altucci, Lucia, Martens, Joost H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986653/
https://www.ncbi.nlm.nih.gov/pubmed/29876014
http://dx.doi.org/10.18632/oncotarget.25429

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