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Analysis of the substrate recognition state of TDP-43 to single-stranded DNA using fluorescence correlation spectroscopy

Normal function and abnormal aggregation of transactivation response (TAR) DNA/RNA-binding protein 43 kDa (TDP-43) are directly associated with the lethal genetic diseases: cystic fibrosis, amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD). The binding of TDP-43 to si...

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Detalles Bibliográficos
Autores principales:	Kitamura, Akira, Shibasaki, Ai, Takeda, Kayo, Suno, Ryoji, Kinjo, Masataka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986658/ https://www.ncbi.nlm.nih.gov/pubmed/29872735 http://dx.doi.org/10.1016/j.bbrep.2018.03.009

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