A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic...

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Detalles Bibliográficos
Autores principales: Szekely, Yishay, Arbel, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986669/
https://www.ncbi.nlm.nih.gov/pubmed/29417406
http://dx.doi.org/10.1007/s40119-018-0104-3
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author Szekely, Yishay
Arbel, Yaron
author_facet Szekely, Yishay
Arbel, Yaron
author_sort Szekely, Yishay
collection PubMed
description Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases.
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spelling pubmed-59866692018-06-13 A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today? Szekely, Yishay Arbel, Yaron Cardiol Ther Review Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases. Springer Healthcare 2018-02-07 2018-06 /pmc/articles/PMC5986669/ /pubmed/29417406 http://dx.doi.org/10.1007/s40119-018-0104-3 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Szekely, Yishay
Arbel, Yaron
A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title_full A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title_fullStr A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title_full_unstemmed A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title_short A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
title_sort review of interleukin-1 in heart disease: where do we stand today?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986669/
https://www.ncbi.nlm.nih.gov/pubmed/29417406
http://dx.doi.org/10.1007/s40119-018-0104-3
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