Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

BACKGROUND: Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous. OBJECTIVE: We sought to investigate the sputum cellular, mediator, and microbiome profiles of both asthma and COPD exacerbations. METHODS: Patients with severe asthma or moderate-to-severe COPD we...

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Detalles Bibliográficos
Autores principales: Ghebre, Michael A., Pang, Pee Hwee, Diver, Sarah, Desai, Dhananjay, Bafadhel, Mona, Haldar, Koirobi, Kebadze, Tatiana, Cohen, Suzanne, Newbold, Paul, Rapley, Laura, Woods, Joanne, Rugman, Paul, Pavord, Ian D., Johnston, Sebastian L., Barer, Michael, May, Richard D., Brightling, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. 2018
Materias:
Asthma and Lower Airway Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986707/
https://www.ncbi.nlm.nih.gov/pubmed/29709671
http://dx.doi.org/10.1016/j.jaci.2018.04.013

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